Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Activation of T cells is dependent on the organized and timely opening and closing of
chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this …

The haploid human genome contains approximately 29 million CpGs that exist in a
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …

Human tumors often contain slowly proliferating cancer cells that resist treatment, but we do
not know precisely how these cells arise. We show that rapidly proliferating cancer cells can …

Activation of T cells is an essential step in the immunological response to infection. Although
activation of naïve T cells results in proliferation and slow differentiation into cytokine …

T cells are exquisitely poised to respond rapidly to pathogens and have proved an
instructive model for exploring the regulation of inducible genes. Individual genes respond …

DNA replication is tightly regulated, but paradoxically there is reported to be an excess of
MCM DNA replication proteins over the number of replication origins. Here, we show that …

In contrast to activated CD4+ T cells and differentiated macrophages, resting CD4+ T cells
and monocytes are non-permissive for HIV-1 replication. The mediators which regulate the …

It is established that histone modifications like acetylation, methylation, phosphorylation and
ubiquitination affect chromatin structure and modulate gene expression. Lysine methylation …