Microbial tryptophan catabolites in health and disease

HM Roager, TR Licht - Nature communications, 2018 - nature.com
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - researchgate.net
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Sesterterpenoids

L Wang, B Yang, XP Lin, XF Zhou, Y Liu - Natural product reports, 2013 - pubs.rsc.org
Covering: October 2006 to June 2012 This review, with 166 references, covers the literature
published on sesterterpenoids together with their relevant biological activities, source …

Antiprotozoal activity profiling of approved drugs: a starting point toward drug repositioning

M Kaiser, P Mäser, LP Tadoori, JR Ioset, R Brun - PloS one, 2015 - journals.plos.org
Neglected tropical diseases cause significant morbidity and mortality and are a source of
poverty in endemic countries. Only a few drugs are available to treat diseases such as …

Antitrypanosomal Quinoline Alkaloids from the Roots of Waltheria indica

S Cretton, L Breant, L Pourrez, C Ambuehl… - Journal of natural …, 2014 - ACS Publications
Chemical investigation of the dichloromethane root extract of Waltheria indica led to the
isolation and characterization of 10 quinoline alkaloids, namely, 8-deoxoantidesmone (1) …

Progress in the chemistry of organic natural products

AD Kinghorn, H Falk, S Gibbons, Y Asakawa, JK Liu… - 2017 - Springer
Termites (Isoptera), which are a suborder of the cockroaches, are the oldest eusocial insects
[1–3]. It is assumed that they diverged from the Cryptocercoidae, woodfeeding cockroaches …

Novel 3-Nitro-1H-1,2,4-triazole-Based Amides and Sulfonamides as Potential Antitrypanosomal Agents

MV Papadopoulou, WD Bloomer… - Journal of Medicinal …, 2012 - ACS Publications
A series of novel 3-nitro-1 H-1, 2, 4-triazole-based (and in some cases 2-nitro-1 H-imidazole-
based) amides and sulfonamides were characterized for their in vitro antitrypanosomal and …

The Laurencia Paradox: An Endless Source of Chemodiversity

M Harizani, E Ioannou, V Roussis - Progress in the chemistry of organic …, 2016 - Springer
Nature, the most prolific source of biological and chemical diversity, has provided mankind
with treatments for health problems since ancient times and continues to be the most …

Tryptophol and derivatives: natural occurrence and applications to the synthesis of bioactive compounds

A Palmieri, M Petrini - Natural product reports, 2019 - pubs.rsc.org
Covering: up to 2018 Tryptophol (indole-3-ethanol) is a metabolite produced by plants,
bacteria, fungi and sponges. This review reports on the natural occurrence, bioactivity and …

Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus ileboensis with potent activities against …

J Li, R Seupel, D Feineis, V Mudogo… - Journal of natural …, 2017 - ACS Publications
Dioncophylline F (1), the first 5, 8′-coupled dioncophyllaceous alkaloid (ie, lacking an
oxygen function at C-6 and possessing an R-configuration at C-3), was isolated from the …