The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …
functions of the different cell types in the exocrine pancreas as well as the roles of these …
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …
[HTML][HTML] The Golgi apparatus is an inositol 1, 4, 5‐trisphosphate‐sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum
In the past few years, intracellular organelles, such as the endoplasmic reticulum, the
nucleus and the mitochondria, have emerged as key determinants in the generation and …
nucleus and the mitochondria, have emerged as key determinants in the generation and …
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
HC Lee - Annual review of pharmacology and toxicology, 2001 - annualreviews.org
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a …
are two Ca2+ messengers derived from NAD and NADP, respectively. Although NAADP is a …
Calcium signalling in astroglia
Astroglia possess excitability based on movements of Ca2+ ions between intracellular
compartments and plasmalemmal Ca2+ fluxes. This “Ca2+ excitability” is controlled by …
compartments and plasmalemmal Ca2+ fluxes. This “Ca2+ excitability” is controlled by …
IP3 receptors: toward understanding their activation
CW Taylor, SC Tovey - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
Inositol 1, 4, 5-trisphosphate receptors (IP3R) and their relatives, ryanodine receptors, are
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …
Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells
M Raraty, J Ward, G Erdemli… - Proceedings of the …, 2000 - National Acad Sciences
The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen
granules in the apical pole. Ca2+ signals elicited by acetylcholine or cholecystokinin (CCK) …
granules in the apical pole. Ca2+ signals elicited by acetylcholine or cholecystokinin (CCK) …
[HTML][HTML] Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate‐evoked local cytosolic Ca2+ signals
H Tinel, JM Cancela, H Mogami… - The EMBO …, 1999 - embopress.org
Agonist‐evoked cytosolic Ca 2+ spikes in mouse pancreatic acinar cells are specifically
initiated in the apical secretory pole and are mostly confined to this region. The role played …
initiated in the apical secretory pole and are mostly confined to this region. The role played …
New functions of a long‐known molecule: Emerging roles of NAD in cellular signaling
M Ziegler - European journal of biochemistry, 2000 - Wiley Online Library
Over the past decades, the pyridine nucleotides have been established as important
molecules in signaling pathways, besides their well known function in energy transduction …
molecules in signaling pathways, besides their well known function in energy transduction …
Polarized calcium signaling in exocrine gland cells
Cytosolic Ca2+ signals are crucial for the control of fluid and enzyme secretion from
exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and …
exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and …