Extracellular vesicles (EVs) encompass a diverse range of membranous structures derived
from cells, including exosomes and microvesicles. These vesicles are present in biological …

Suppression of premature termination codons (PTCs) by translational readthrough is a
promising strategy to treat a wide variety of severe genetic diseases caused by nonsense …

Identification of drug targets and biochemical investigations on mechanisms of action are
major issues in modern drug development. The present article is a critical review of the …

Leucinostatins are antimicrobial peptides with a broad range of activities against infectious
agents as well as mammalian cells. The leucinostatin-derivative peptide ZHAWOC_6027 …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The
prognosis for patients with high-grade and metastatic disease is still very poor, and survivors …

The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside
(GC008) and artemisone (GC003) are potent antimalarials. The mode of action of …

Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive
fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as …

Background Benign prostatic hyperplasia in elderly males often causes bladder outlet
obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract …

In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a
suitable tool to identify the role of specific genes. The general consensus implies that only …

Abstract Treatment of pneumococcal infections is limited by antibiotic resistance and
exacerbation of disease by bacterial lysis releasing pneumolysin toxin and other …