Non‐invasive prenatal testing (NIPT) for aneuploidy using cell‐free DNA in maternal plasma
is revolutionizing prenatal screening and diagnosis. We review NIPT in the context of …

Digital polymerase chain reaction (dPCR) technology has provided a new technique for
molecular diagnostics, with superior advantages, such as higher sensitivity, precision, and …

Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …

Deoxyribonucleic acid (DNA) of the human immunodeficiency virus (HIV) provides the most
sensitive measurement of residual infection in patients on effective combination antiretroviral …

Objectives To validate the clinical efficacy and practical feasibility of massively parallel
maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk …

Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis.
Current methods for definitive diagnosis rely on invasive procedures, such as chorionic …

Maternal plasma contains circulating cell‐free DNA fragments originating from both the
mother and the placenta. The proportion derived from the placenta is known as the fetal …

OBJECTIVE: We sought to evaluate performance of a noninvasive prenatal test for fetal
trisomy 21 (T21) and trisomy 18 (T18). STUDY DESIGN: A multicenter cohort study was …

Noninvasive prenatal testing using fetal DNA in maternal plasma is an actively researched
area. The current generation of tests using massively parallel sequencing is based on …

OBJECTIVE: We sought to evaluate a multiplexed massively parallel shotgun sequencing
assay for noninvasive trisomy 21 detection using circulating cell-free fetal DNA. STUDY …