Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-Cov-2 variants

V Tchesnokova, H Kulasekara, L Larson… - Journal of clinical …, 2021 - journals.asm.org
We report that there is a recent global expansion of numerous independent severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the …

A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

A Tauzin, M Nayrac, M Benlarbi, SY Gong, R Gasser… - Cell host & …, 2021 - cell.com
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two
doses administered 3 weeks apart, some public health authorities are spacing these doses …

COVID-19 and the clinical course of rheumatic manifestations

S Ahmed, O Zimba, AY Gasparyan - Clinical rheumatology, 2021 - Springer
The manifestations of COVID-19 have been evolving over time. Various post-COVID-19
syndromes are being recognised. Various viruses have been implicated in the pathogenesis …

Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response

Y Jiao, P Zhao, LD Xu, JQ Yu, HL Cai, C Zhang… - Autophagy, 2024 - Taylor & Francis
ABSTRACT Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its
primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine …

Whole genome sequencing of SARS-CoV2 strains circulating in Iran during five waves of pandemic

J Yavarian, A Nejati, V Salimi, NZ Shafiei Jandaghi… - PLoS …, 2022 - journals.plos.org
Purpose Whole genome sequencing of SARS-CoV2 is important to find useful information
about the viral lineages, variants of interests and variants of concern. As there are not …

A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

A Tauzin, M Nayrac, M Benlarbi, SY Gong, R Gasser… - Biorxiv, 2021 - biorxiv.org
The standard dosing of the Pfizer/BioNTech BNT162b2 mRNA vaccine validated in clinical
trials includes two doses administered three weeks apart. While the decision by some public …

[HTML][HTML] Whole-genome sequencing of SARS-CoV-2 reveals diverse mutations in circulating Alpha and Delta variants during the first, second, and third waves of …

PB Ntagereka, SO Oyola, SP Baenyi, GK Rono… - International Journal of …, 2022 - Elsevier
Objectives We used whole-genome sequencing of SARS-CoV-2 to identify variants
circulating in the Democratic Republic of the Congo and obtain molecular information useful …

[HTML][HTML] SARS-CoV-2 infectivity and severity of COVID-19 according to SARS-CoV-2 variants: current evidence

TL Dao, VT Hoang, P Colson, JC Lagier… - Journal of clinical …, 2021 - mdpi.com
Background: We conducted this review to summarize the relation between viral mutation
and infectivity of SARS-CoV-2 and also the severity of COVID-19 in vivo and in vitro. Method …