Toll like receptor 9 (TLR9) has been considered as a crucial intracellular pattern recognition
receptor in the immune system, which can directly or indirectly mediate innate and adaptive …

Severe sepsis represents a common, expensive, and deadly health care issue with limited
therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis …

Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus
erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the …

Increased levels of circulating cell‐free DNA (cfDNA) are associated with poor clinical
outcomes in patients with acute kidney injury (AKI). Scavenging cfDNA by nanomaterials is …

Inhibitory oligodeoxynucleotides (ODNs) are short single-stranded DNA, which capable of
folding into complex structures, enabling them to bind to a large variety of targets. With …

Neutrophils exert either pro-or anti-tumor activities. However, few studies have focused on
neutrophils at the tumor initiation stage. In this study, we unexpectedly found a …

Sterile inflammation contributes to many pathological states associated with mitochondrial
injury. Mitochondrial injury disrupts calcium homeostasis and results in the release of CpG …

In acute pancreatitis, histones are released by infiltrating neutrophils, but how histones
modulate pancreatic acinar cell function has not been investigated. We have examined …

Neutrophils, classified as professional phagocytes, are crucial in killing bacteria and
preventing inflammation. When studying the roles of neutrophils in the development of the …

Objective To investigate the expression and clinical significance of blood basophil CD16
and CD32 in asthmachronic obstructive pulmonary disease overlap (ACO) and chronic …