Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Uropathogenic Escherichia coli (UPEC) are one of the most common agents of urinary tract
infection. In the last decade, several UPEC strains have acquired antibiotic resistance …

Bacterial lipoproteins (BLPs) decorate the surface of membranes in the cell envelope. They
function in membrane assembly and stability, as enzymes, and in transport. The final …

In recent decades, accumulating research on the interactions between microbiome
homeostasis and host health has broadened new frontiers in delineating the molecular …

An outer membrane (OM) is the hallmark feature that is often used to distinguish “Gram-
negative” bacteria. Our understanding of how the OM is built rests largely on studies of …

Acinetobacter baumannii is a clinically important, predominantly health care–associated
gram-negative bacterium with high rates of emerging resistance worldwide. Given the urgent …

Lipoproteins are some of the most abundant proteins in bacteria. With a lipid anchor to the
cell membrane, they function as enzymes, inhibitors, transporters, structural proteins, and as …

Tandem gene amplification is a frequent and dynamic source of antibiotic resistance in
bacteria. Ongoing expansions and contractions of repeat arrays during population growth …

Lipoprotein diacylglyceryl transferase (Lgt) catalyzes the first step in the biogenesis of Gram-
negative bacterial lipoproteins which play crucial roles in bacterial growth and …

The increasing prevalence of antibiotic resistance demands the discovery of antibacterial
chemical scaffolds with unique mechanisms of action. Phenotypic screening approaches …