Recent progress of solid lipid nanoparticles and nanostructured lipid carriers as ocular drug delivery platforms

V Gugleva, V Andonova - Pharmaceuticals, 2023 - mdpi.com
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to
the complex structure of the eye and its protective physiological mechanisms. In addition, the …

Lipid-based nanocarriers challenging the ocular biological barriers: Current paradigm and future perspectives

KK Abla, MM Mehanna - Journal of Controlled Release, 2023 - Elsevier
Eye is the most specialized and sensory body organ and treating eye diseases efficiently is
necessary. Despite various attempts, the design of a consummate ophthalmic drug delivery …

[HTML][HTML] Artificial intelligence for visually impaired

J Wang, S Wang, Y Zhang - Displays, 2023 - Elsevier
The eyes are an essential tool for human observation and perception of the world, hel**
people to perform their tasks. Visual impairment causes many inconveniences in the lives of …

Role of polymeric micelles in Ocular Drug Delivery: an overview of decades of Research

Z Binkhathlan, R Ali, AH Alomrani… - Molecular …, 2023 - ACS Publications
Local drug delivery to the eye through conventional means has faced many challenges due
to three essential barriers:(a) the complex structure of the cornea limiting drug absorption,(b) …

[HTML][HTML] BCLA CLEAR Presbyopia: Mechanism and optics

LN Davies, S Biswas, M Bullimore… - Contact Lens and …, 2024 - Elsevier
With over a billion adults worldwide currently affected, presbyopia remains a ubiquitous,
global problem. Despite over a century of study, the precise mechanism of ocular …

Commercial hydrogel product for drug delivery based on route of administration

A Raeisi, F Farjadian - Frontiers in Chemistry, 2024 - frontiersin.org
Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant
amounts of biological fluids or water. Hydrogels possess several favorable properties …

[HTML][HTML] Desired properties of polymeric hydrogel vitreous substitute

S Qu, Y Tang, Z Ning, Y Zhou, H Wu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Vitreous replacement is a commonly employed method for treating a range of ocular
diseases, including posterior vitreous detachment, complex retinal detachment, diabetic …

Programming viscoelastic properties in a complexation gel composite by utilizing entropy-driven topologically frustrated dynamical state

GK Wang, YM Yang, D Jia - Nature Communications, 2024 - nature.com
Hydrogel composites in an aqueous media with viscoelastic properties and elastic modulus
that can be precisely tailored are desirable to mimic many biological tissues ranging from …

Silk fibroin/vitreous humor hydrogel scaffold modified by a carbodiimide crosslinker for wound healing

S Rafiei, M Ghanbari‐Abdolmaleki, R Zeinali… - …, 2024 - Wiley Online Library
Natural‐derived biomaterials can be used as substrates for the growth, proliferation, and
differentiation of cells. In this study, bovine vitreous humor as a biological material was cross …

In situ gels: The next new frontier in ophthalmic drug delivery system

G Sha, J Liu, Z Jiang, M Zhu, Y Zhu… - Polymers for …, 2023 - Wiley Online Library
Recently, the eye drug delivery system has received increasing attention. The in situ
ophthalmic gel is a semisolid ophthalmic preparation that can be changed in the eyes …