Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability

S Maksour, RK Finol-Urdaneta, AJ Hulme… - Frontiers in Cellular …, 2024 - frontiersin.org
Alzheimer's disease (AD) is a devastating neurodegenerative condition that affects memory
and cognition, characterized by neuronal loss and currently lacking a cure. Mutations in …

MALDI-2-enabled oversampling for the mass spectrometry imaging of metabolites at single-cell resolution

JC McKinnon, R Balez, RSE Young… - Journal of the …, 2024 - ACS Publications
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can
provide valuable insights into the metabolome of complex biological systems such as organ …

Visualization of incrementally learned projection trajectories for longitudinal data

T Malepathirana, D Senanayake, V Gautam… - Scientific Reports, 2024 - nature.com
Longitudinal studies that continuously generate data enable the capture of temporal
variations in experimentally observed parameters, facilitating the interpretation of results in a …

Astrocytic glutamate regulation is implicated in the development of stress-related psychiatric disorders

D Kaul, AR Curry, N Gerstner, A Froehlich, CC Smith… - bioRxiv, 2024 - biorxiv.org
Severe psychological stress is one of the most potent risk factors for develo** a mood or
psychotic disorder, yet the underlying molecular mechanisms are poorly understood …

Dynamic balance of H3K9me2 heterochromatin by CoREST-2 and RE-1 in growing neurons

JF Drube, A Cardozo-Gizzi, V Rozes-Salvador… - bioRxiv, 2025 - biorxiv.org
A well-balanced chromatin dynamic is vital for the survival and physiology of all cells,
including brain neurons. Heterochromatin, commonly associated with transcriptional …

THE EFFECT OF SERTRALINE AND VOLUNTARY EXERCISE DURING PREGNANCY ON LITTER CHARACTERISTICS AND POSTNATAL AFFECTIVE BEHAVIOUR …

NS Jarbou, O Mairinger, E Kulen, L Mushahwar… - bioRxiv, 2025 - biorxiv.org
Introduction: Sertraline is the frontline pharmacotherapy for the treatment of depression and
anxiety during pregnancy. However, there is little evidence regarding the effects of sertraline …