Cancer is a disease that undergoes selective pressure to evolve during its progression,
becoming increasingly heterogeneous. Tumoral heterogeneity can dictate therapeutic …

Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …

In recent years, single-cell analyses have revealed the heterogeneity of the tumour
microenvironment (TME) at the genomic, transcriptomic, and proteomic levels, further …

Cancer cells have a high demand for sugars and express diverse carbohydrate receptors,
offering opportunities to improve delivery with multivalent glycopolymer materials. However …

Exploring the molecular mechanisms of PD-1/PDL-1 blockade for non-small cell lung cancer
(NSCLC) would facilitate understanding for tumor microenvironment (TME) and …

Single-cell sequencing is a high-throughput technique that enables detection of genomic,
transcriptomic, and epigenomic information at the individual cell level, offering significant …

Background Lung cancer is a prevalent form of cancer worldwide, presenting a substantial
risk to human well-being. Lung cancer is classified into two main types: non-small cell lung …

The PD1/PD-L1 axis plays an important immunosuppressive role during the T-cell-mediated
immune response, which is essential for the physiological homeostasis of the immune …

Pancreatic cancer remains one of the deadliest malignancies with an overall 5-year survival
rate of 13%. This dismal fact can be partly attributed to currently limited understanding of …

The pathogenesis of pancreatic cancer involves substantial metabolic reprogramming,
resulting in abnormal proliferation of tumor cells. This tumorigenic reprogramming is often …