The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis
AL Drumond-Bock, M Bieniasz - Molecular Cancer, 2021 - Springer
High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian
cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of …
cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of …
Effect of Propofol on breast Cancer cell, the immune system, and patient outcome
Breast cancer is the second leading cause of cancer death in women. Surgery is the first line
of treatment for breast cancer. Retrospective clinical studies suggest that the type of …
of treatment for breast cancer. Retrospective clinical studies suggest that the type of …
Frequency and spectrum of PIK3CA somatic mutations in breast cancer
Abstract Purpose The therascreen PIK3CA mutation assay and the alpha-specific PI3K
inhibitor alpelisib are FDA-approved for identifying and treating patients with advanced …
inhibitor alpelisib are FDA-approved for identifying and treating patients with advanced …
Evaluation of variable selection methods for random forests and omics data sets
F Degenhardt, S Seifert… - Briefings in bioinformatics, 2019 - academic.oup.com
Abstract Machine learning methods and in particular random forests are promising
approaches for prediction based on high dimensional omics data sets. They provide …
approaches for prediction based on high dimensional omics data sets. They provide …
A benchmark study of deep learning-based multi-omics data fusion methods for cancer
D Leng, L Zheng, Y Wen, Y Zhang, L Wu, J Wang… - Genome biology, 2022 - Springer
Background A fused method using a combination of multi-omics data enables a
comprehensive study of complex biological processes and highlights the interrelationship of …
comprehensive study of complex biological processes and highlights the interrelationship of …
NeoPalAna: neoadjuvant palbociclib, a cyclin-dependent kinase 4/6 inhibitor, and anastrozole for clinical stage 2 or 3 estrogen receptor–positive breast cancer
Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor–
positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) …
positive (ER+) breast cancer. This single-arm phase II neoadjuvant trial (NeoPalAna) …
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
Background One of the hallmarks of cancer is the disruption of gene expression patterns.
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …
Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA …
Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
Evidence suggests that the catabolic process of macroautophagy (autophagy hereafter) can
either suppress or promote cancer. The essential autophagy gene ATG6/BECN1 encoding …
either suppress or promote cancer. The essential autophagy gene ATG6/BECN1 encoding …
GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
HL Goel, B Pursell, C Chang, LM Shaw… - EMBO molecular …, 2013 - embopress.org
The characterization of cells with tumour initiating potential is significant for advancing our
understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers …
understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers …
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer.
Drug development efforts have been focused on kinases in this pathway, most notably on …
Drug development efforts have been focused on kinases in this pathway, most notably on …