CTLs heterogeneity and plasticity: implications for cancer immunotherapy

S Peng, A Lin, A Jiang, C Zhang, J Zhang, Q Cheng… - Molecular Cancer, 2024 - Springer
Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …

Histone deacetylase function in CD4+ T cells

W Ellmeier, C Seiser - Nature Reviews Immunology, 2018 - nature.com
The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …

Butyrate ameliorates caerulein‐induced acute pancreatitis and associated intestinal injury by tissue‐specific mechanisms

X Pan, X Fang, F Wang, H Li, W Niu… - British journal of …, 2019 - Wiley Online Library
Background and Purpose Acute pancreatitis (AP) is a common acute abdominal condition,
frequently associated with intestinal barrier dysfunction, which aggravates AP retroactively …

The CC chemokines CCL17 and CCL22 and their receptor CCR4 in CNS autoimmunity

S Scheu, S Ali, C Ruland, V Arolt, J Alferink - International journal of …, 2017 - mdpi.com
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). It affects more than two million people worldwide, mainly young …

Immune modulatory effects of ketogenic diet in different disease conditions

S Srivastava, VA Pawar, A Tyagi, KP Sharma, V Kumar… - Immuno, 2022 - mdpi.com
Interceding nutrients have been acquiring increased attention and prominence in the field of
healing and deterrence of various disorders. In this light, the present article encompasses …

Autoantibodies as diagnostic markers and mediator of joint inflammation in arthritis

Q Fang, J Ou, KS Nandakumar - Mediators of inflammation, 2019 - Wiley Online Library
Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by
erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against …

[HTML][HTML] Role of ketogenic diets in multiple sclerosis and related animal models: An updated review

WS Lin, SJ Lin, PY Liao, D Suresh, TR Hsu… - Advances in …, 2022 - Elsevier
Prescribing a ketogenic diet (KD) is a century-old dietary intervention mainly used in the
context of intractable epilepsy. The classic KD and its variants regained popularity in recent …

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis

L Göschl, T Preglej, N Boucheron, V Saferding… - Journal of …, 2020 - Elsevier
Rheumatoid Arthritis (RA) represents a chronic T cell-mediated inflammatory autoimmune
disease. Studies have shown that epigenetic mechanisms contribute to the pathogenesis of …

[HTML][HTML] Role of Epigenetics in the Regulation of Immune Functions of the Skin

Y Sawada, RL Gallo - Journal of Investigative Dermatology, 2021 - Elsevier
This review is intended to illuminate the emerging understanding of epigenetic modifications
that regulate both adaptive and innate immunity in the skin. Host defense of the epidermis …

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

ER Webb, GL Dodd, M Noskova, E Bullock, M Muir… - Elife, 2023 - elifesciences.org
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated
with metastasis-free survival; however, the mechanisms involved are poorly understood …