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CTLs heterogeneity and plasticity: implications for cancer immunotherapy
Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …
Histone deacetylase function in CD4+ T cells
The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …
accompanied by changes in gene expression programmes, which in part are regulated and …
Butyrate ameliorates caerulein‐induced acute pancreatitis and associated intestinal injury by tissue‐specific mechanisms
X Pan, X Fang, F Wang, H Li, W Niu… - British journal of …, 2019 - Wiley Online Library
Background and Purpose Acute pancreatitis (AP) is a common acute abdominal condition,
frequently associated with intestinal barrier dysfunction, which aggravates AP retroactively …
frequently associated with intestinal barrier dysfunction, which aggravates AP retroactively …
The CC chemokines CCL17 and CCL22 and their receptor CCR4 in CNS autoimmunity
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). It affects more than two million people worldwide, mainly young …
nervous system (CNS). It affects more than two million people worldwide, mainly young …
Immune modulatory effects of ketogenic diet in different disease conditions
Interceding nutrients have been acquiring increased attention and prominence in the field of
healing and deterrence of various disorders. In this light, the present article encompasses …
healing and deterrence of various disorders. In this light, the present article encompasses …
Autoantibodies as diagnostic markers and mediator of joint inflammation in arthritis
Q Fang, J Ou, KS Nandakumar - Mediators of inflammation, 2019 - Wiley Online Library
Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by
erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against …
erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against …
[HTML][HTML] Role of ketogenic diets in multiple sclerosis and related animal models: An updated review
WS Lin, SJ Lin, PY Liao, D Suresh, TR Hsu… - Advances in …, 2022 - Elsevier
Prescribing a ketogenic diet (KD) is a century-old dietary intervention mainly used in the
context of intractable epilepsy. The classic KD and its variants regained popularity in recent …
context of intractable epilepsy. The classic KD and its variants regained popularity in recent …
Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis
L Göschl, T Preglej, N Boucheron, V Saferding… - Journal of …, 2020 - Elsevier
Rheumatoid Arthritis (RA) represents a chronic T cell-mediated inflammatory autoimmune
disease. Studies have shown that epigenetic mechanisms contribute to the pathogenesis of …
disease. Studies have shown that epigenetic mechanisms contribute to the pathogenesis of …
[HTML][HTML] Role of Epigenetics in the Regulation of Immune Functions of the Skin
Y Sawada, RL Gallo - Journal of Investigative Dermatology, 2021 - Elsevier
This review is intended to illuminate the emerging understanding of epigenetic modifications
that regulate both adaptive and innate immunity in the skin. Host defense of the epidermis …
that regulate both adaptive and innate immunity in the skin. Host defense of the epidermis …
Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models
ER Webb, GL Dodd, M Noskova, E Bullock, M Muir… - Elife, 2023 - elifesciences.org
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated
with metastasis-free survival; however, the mechanisms involved are poorly understood …
with metastasis-free survival; however, the mechanisms involved are poorly understood …