During a single human lifetime, nearly one quintillion chromosomes separate from their
sisters and transit to their destinations in daughter cells. Unlike DNA replication …

Neocentromeres are ectopic sites where new functional kinetochores assemble and permit
chromosome segregation. Neocentromeres usually form following genomic alterations that …

Fungal pathogens pose a global threat to human health, with Candida albicans among the
leading killers. Systematic analysis of essential genes provides a powerful strategy to …

Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …

Candida albicans, the most prevalent human fungal pathogen, is generally diploid.
However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used …

In Drosophila melanogaster, as in many animal and plant species, centromere identity is
specified epigenetically. In proliferating cells, a centromere-specific histone H3 variant …

The stoichiometries of kinetochores and their constituent proteins in yeast and vertebrate
cells were determined using the histone H3 variant CENP-A, known as Cse4 in budding …

In most eukaryotes, centromere is determined by the presence of the centromere-specific
histone variant CenH3. Two types of chromosome morphology are generally recognized …

The centromere, on which kinetochore proteins assemble, ensures precise chromosome
segregation. Centromeres are largely specified by the histone H3 variant CENP-A (also …

Candida albicans is an important opportunistic fungal pathogen capable of causing both
mucosal and disseminated disease. Infections are often treated with fluconazole, a front-line …