Green metric tools for analytical methods assessment critical review, case studies and crucify

LP Kowtharapu, NK Katari, SK Muchakayala… - TrAC Trends in …, 2023 - Elsevier
Metrics for green chemistry are to identify features of a chemical process that adhere to the
green chemistry principles. Several metrics are available for assessing analytical method …

Exploring sustainable analytical techniques using G score and future innovations in green analytical chemistry

KP Kannaiah, HK Chanduluru - Journal of Cleaner Production, 2023 - Elsevier
Sustainable practices in analytical chemistry are essential in light of global environmental
concerns. Green Analytical Chemistry (GAC) offers eco-friendly and sustainable analytical …

AQbD based green UPLC method to determine mycophenolate mofetil impurities and Identification of degradation products by QToF LCMS

SK Muchakayala, NK Katari, KK Saripella, H Schaaf… - Scientific Reports, 2022 - nature.com
We report an ideal method for quantifying impurities in mycophenolate mofetil drug
substances and their oral suspension preparations. We developed a systematic and eco …

Application of advanced environmentally benign assessment tools in determining ternary cardiovascular drug combination by RP-HPLC with analytical quality by …

KP Kannaiah, HK Chanduluru, RH Obaydo… - Sustainable Chemistry …, 2023 - Elsevier
Assessing any analytical method is becoming an important aspect for showcasing its
importance and impact on the environment. The present work aimed to showcase different …

Green chromatographic method for determination of active pharmaceutical ingredient, preservative, and antioxidant in an injectable formulation: Robustness by …

LP Kowtharapu, NK Katari, CA Sandoval… - ACS …, 2022 - ACS Publications
We report an efficient HPLC method for simultaneous qualitative and quantitative analysis of
lincosamide antibiotic injectable formulations containing Clindamycin phosphate (CMN) …

Simultaneous estimation of crotamiton and hydrocortisone by RP-UPLC using green analytical principles embedded analytical quality by design (AQbD) method

KP Kannaiah, A Sugumaran, HK Chanduluru - Microchemical Journal, 2023 - Elsevier
Analyzing varied concentrations of pharmaceutical active drug substances in dosage forms
without any interferences using eco-friendly principles is more challenging. Hence, the aim …

Unique green chromatographic method for the qualitative and quantitative analysis of ketoconazole, its impurities and preservatives from ketoconazole cream …

SK Muchakayala, NK Katari, KK Saripella… - Sustainable Chemistry …, 2023 - Elsevier
Current research portrays a simultaneous determination method for the qualitative and
quantitative analysis of Ketoconazole, its impurities and preservatives from Ketoconazole …

QbD green analytical procedure for Novel study of a genotoxic and carcinogenic compound trace determination in physiological solution compatibility

LP Kowtharapu, NK Katari, SK Muchakayala… - Sustainable Chemistry …, 2023 - Elsevier
Regulatory bodies more focusses on the safety and efficacy of the pharmaceuticals, through
this work we want to express the necessary control of 5-Hydroxymethyl furfural (5-HMF) …

Method development and validation of Atorvastatin, Ezetimibe and Fenofibrate using RP-HPLC along with their forced degradation studies and greenness profiling

V Sukumar, S Chinnusamy… - … Chemistry Letters and …, 2023 - Taylor & Francis
The present study aimed to separate the three-drug combination and degradant products by
applying stress studies in bulk and pharmaceutical using RP-HPLC green analytical …

Development and validation of novel RP‐HPLC method for midostaurin determination using analytical quality by design approach from regulatory perspective and …

MP Reddy Saddala, N Konduru… - Biomedical …, 2022 - Wiley Online Library
Midostaurin (MTN), designated as an orphan medicinal product, is emerging as an important
drug for treating acute myeloid leukemia and advanced systematic mastocytosis. The …