Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
H Zhang, L Liu, J Liu, P Dang, S Hu, W Yuan, Z Sun… - Molecular Cancer, 2023 - Springer
In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
Noncoding RNA therapeutics—challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
Antagomir technology in the treatment of different types of cancer
Cancer is associated with abnormal cell growth that may invade or spread to several other
areas of the body. It is a noncommunicable disease that in recent decades has been …
areas of the body. It is a noncommunicable disease that in recent decades has been …
[HTML][HTML] Emerging roles of lncRNA in cancer and therapeutic opportunities
MC Jiang, JJ Ni, WY Cui, BY Wang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Cancer is difficult to cure due to frequent metastasis, and develo** effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to …
D **, J Guo, Y Wu, J Du, L Yang, X Wang, W Di… - Journal of hematology & …, 2019 - Springer
Background METTL3 is an RNA methyltransferase that mediates m 6 A modification and is
implicated in mRNA biogenesis, decay, and translation. However, the biomechanism …
implicated in mRNA biogenesis, decay, and translation. However, the biomechanism …
Non-coding RNAs and potential therapeutic targeting in cancer
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …
Long noncoding RNAs in cancer pathways
AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …
mutations within the noncoding genome, with profound effects on the expression of long …
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric …
X Qu, B Liu, L Wang, L Liu, W Zhao, C Liu, J Ding… - Drug Resistance …, 2023 - Elsevier
Abstract Aims Long non-coding RNAs (lncRNAs), as one of the components of exosomes
derived from cancer-associated fibroblasts (CAFs), exhibit a crucial role in the pathogenesis …
derived from cancer-associated fibroblasts (CAFs), exhibit a crucial role in the pathogenesis …