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Multi-omics data integration methods and their applications in psychiatric disorders
To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews
Background The etiologies of chronic neurological diseases, which heavily contribute to
global disease burden, remain far from elucidated. Despite available umbrella reviews on …
global disease burden, remain far from elucidated. Despite available umbrella reviews on …
TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies
Transcriptome-wide association studies (TWASs), as a practical and prevalent approach for
detecting the associations between genetically regulated genes and traits, are now leading …
detecting the associations between genetically regulated genes and traits, are now leading …
[HTML][HTML] Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis …
The potential etiological role of early acetaminophen exposure on Autism Spectrum
Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We …
Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We …
Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions
Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in
major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform …
major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform …
Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders
Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …
causes of disability worldwide. However, only limited drugs are available for psychiatric …
[HTML][HTML] Delineating the genetic component of gene expression in major depression
Background Major depression (MD) is determined by a multitude of factors including genetic
risk variants that regulate gene expression. We examined the genetic component of gene …
risk variants that regulate gene expression. We examined the genetic component of gene …
A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine
J Gui, X Yang, C Tan, L Wang, L Meng, Z Han… - The journal of headache …, 2024 - Springer
Background Migraine is a common neurological disorder with a strong genetic component.
Despite the identification of over 100 loci associated with migraine susceptibility through …
Despite the identification of over 100 loci associated with migraine susceptibility through …
Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways
The attentional control of behavior is a higher-order cognitive function that operates through
attention and response inhibition. The locus coeruleus (LC), the main source of …
attention and response inhibition. The locus coeruleus (LC), the main source of …
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
loci associated with Alzheimer's disease (AD), but the genes responsible for these …