The receptor tyrosine kinase AXL, activated by a complex interaction between its ligand
growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular …

Epithelial–mesenchymal transition (EMT) programs play essential functions in normal
morphogenesis and organogenesis, including that occurring during mammary gland …

As central nodes in cardiomyocyte signaling, nuclear AKT appears to play a cardio-
protective role in cardiovascular disease. Here we describe a circular RNA, circ-Amotl1 that …

Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA
from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who …

A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients
with EGFR-mutated lung cancer. However, some patients show intrinsic resistance and an …

Intratumor heterogeneity is a key factor contributing to therapeutic failure and, hence, cancer
lethality. Heterogeneous tumors show partial therapy responses, allowing for the emergence …

Background Gastric cancer is one of the major causes of cancer-related mortality worldwide.
Most of patients presenting with inoperable gastric cancers rely on systemic chemotherapy …

AXL is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family
(RTKs), and its abnormal expression has been linked to clinicopathological features and …

Anti-HER2 therapies have markedly improved prognosis of HER2-positive breast cancer.
However, different mechanisms play a role in treatment resistance. Here, we identified AXL …

The receptor tyrosine kinase (RTK) AXL has been intrinsically linked to epithelial–
mesenchymal transition (EMT) and promoting cell survival, anoikis resistance, invasion, and …