Systems biology and synthetic biology are increasingly used to examine and modulate
complex biological systems. As such, many issues arising during scaling-up microbial …

Bacteria use dedicated mechanisms to respond adequately to fluctuating environments and
to optimize their chances of survival in harsh conditions. One of the major stress responses …

Gut dysbiosis during inflammatory bowel disease involves alterations in the gut microbiota
associated with inflammation of the host gut. We used a combination of shotgun …

In the face of climate change, progressive degradation of the environment, including
agricultural land negatively affecting plant growth and development, endangers plant …

The stringent response is a conserved bacterial stress response mechanism that allows
bacteria to respond to nutritional challenges. It is mediated by the alarmones pppGpp and …

Since Jacques Monod's foundational work in the 1940s, investigators studying bacterial
physiology have largely (but not exclusively) focused on the exponential phase of bacterial …

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen causing chronic
infections that are associated with the sessile/biofilm mode of growth rather than the free …

Globally, agriculture depends on industrial nitrogen fertilizer to improve crop growth.
Fertilizer production consumes fossil fuels and contributes to environmental nitrogen …

In adapting to the intracellular niche, obligate intracellular bacteria usually undergo a
reduction of genome size by eliminating genes not needed for intracellular survival. These …

Bacteria adapt to environmental stress by producing proteins that provide stress protection.
However, stress can severely perturb the kinetics of gene expression, disrupting protein …