[HTML][HTML] Pathophysiology of acute myeloid leukemia
Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …
Mechanisms associated with t (7; 12) acute myeloid leukaemia: from genetics to potential treatment targets
Acute myeloid leukaemia (AML), typically a disease of elderly adults, affects 8 children per
million each year, with the highest paediatric incidence in infants aged 0–2 of 18 per million …
million each year, with the highest paediatric incidence in infants aged 0–2 of 18 per million …
Alterations in Genome Organization in Lymphoma Cell Nuclei due to the Presence of the t (14; 18) Translocation
E Garimberti, C Federico, D Ragusa, F Bruno… - International Journal of …, 2024 - mdpi.com
Chromosomal rearrangements have been shown to alter genome organization,
consequently having an impact on gene expression. Studies on certain types of leukemia …
consequently having an impact on gene expression. Studies on certain types of leukemia …
Aberrant MNX1 expression associated with t (7; 12)(q36; p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation
A Waraky, A Östlund, T Nilsson, D Weichenhan… - …, 2023 - pmc.ncbi.nlm.nih.gov
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such
as AML with translocation t (7; 12)(q36; p13) leading to an MNX1:: ETV6 fusion along with …
as AML with translocation t (7; 12)(q36; p13) leading to an MNX1:: ETV6 fusion along with …
Robertsonian Translocation between Human Chromosomes 21 and 22, Inherited across Three Generations, without Any Phenotypic Effect
C Federico, D Brancato, F Bruno, D Galvano, M Caruso… - Genes, 2024 - mdpi.com
Chromosomal translocations can result in phenotypic effects of varying severity, depending
on the position of the breakpoints and the rearrangement of genes within the interphase …
on the position of the breakpoints and the rearrangement of genes within the interphase …
Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
Current in vitro models of developmental blood formation lack spatiotemporal coherence
and weakly replicate the hematopoietic microenvironment. Developmentally-appropriate …
and weakly replicate the hematopoietic microenvironment. Developmentally-appropriate …
Pathophysiology of Acute Myeloid Leukemia
Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …
Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q
Acute myeloid leukemia with complex karyotype (ckAML) is characterized by high genomic
complexity, including frequent TP53 mutations and chromothripsis. We hypothesized that the …
complexity, including frequent TP53 mutations and chromothripsis. We hypothesized that the …
Mnx1 induces leukemia transformation through altering histone methylation in a model of pediatric t (7; 12) acute myeloid leukemia
A Waraky, A Östlund, T Nilsson, D Weichenhan… - Bior**v, 2022 - biorxiv.org
Acute myeloid leukemia (AML) in children with certain genetic aberrations is still associated
with inferior outcome. One of these AML subtypes has a translocation t (7; 12)(q36; p13) and …
with inferior outcome. One of these AML subtypes has a translocation t (7; 12)(q36; p13) and …
Epigenetic compound screening in AML with MNX1 overexpression
S Kelekçi - 2024 - archiv.ub.uni-heidelberg.de
Acute myeloid leukemia (AML) is a form of blood cancer characterized by impaired
differentiation and accelerated proliferation due to (epi) genetic dysregulation of …
differentiation and accelerated proliferation due to (epi) genetic dysregulation of …