Construction and characterization of virus-like particles: a review

A Zeltins - Molecular biotechnology, 2013 - Springer
Over the last three decades, virus-like particles (VLPs) have evolved to become a widely
accepted technology, especially in the field of vaccinology. In fact, some VLP-based …

Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures

P Pushko, P Pumpens, E Grens - Intervirology, 2013 - karger.com
Virus-like particle (VLP) technology is a promising approach for the construction of novel
vaccines, diagnostic tools, and gene therapy vectors. Initially, VLPs were primarily derived …

The optimized capsid gene of porcine circovirus type 2 expressed in yeast forms virus-like particles and elicits antibody responses in mice fed with recombinant yeast …

SA Bucarey, J Noriega, P Reyes, C Tapia, L Sáenz… - Vaccine, 2009 - Elsevier
Porcine circovirus type 2 (PCV2)-associated diseases are considered to be the biggest
problem for the worldwide swine industry. The PCV2 capsid protein (Cap) is an important …

Characterization of protective humoral and cellular immune responses against RHDV2 induced by a new vaccine based on recombinant baculovirus

C Müller, R Ulrich, J Schinköthe, M Müller, B Köllner - Vaccine, 2019 - Elsevier
Rabbit hemorrhagic disease (RHD) is a lethal disease in rabbits caused by RHD virus
(RHDV). Protection is only possible through vaccination. A new virus variant (RHDV2) which …

High-level expression and immunogenicity of a porcine circovirus type 2 capsid protein through codon optimization in Pichia pastoris

Y Tu, Y Wang, G Wang, J Wu, Y Liu, S Wang… - Applied microbiology …, 2013 - Springer
The porcine circovirus type 2 (PCV2) capsid protein (Cap) is an important antigen for the
development of vaccines. To achieve high-level expression of recombinant PCV2 Cap in …

Adjuvant effects of interleukin-2 co-expression with VP60 in an oral vaccine delivered by attenuated Salmonella typhimurium against rabbit hemorrhagic disease

Z Deng, Y Geng, K Wang, Z Yu, PO Yang, Z Yang… - Veterinary …, 2019 - Elsevier
Rabbit hemorrhagic disease (RHD) is a highly contagious infection that has caused
significant damage to the rabbit industry since 1984. Inactivated vaccines, the currently used …

Conformational and thermal stability improvements for the large-scale production of yeast-derived rabbit hemorrhagic disease virus-like particles as multipurpose …

E Fernández, JR Toledo, L Méndez, N González… - PLoS …, 2013 - journals.plos.org
Recombinant virus-like particles (VLP) antigenically similar to rabbit hemorrhagic disease
virus (RHDV) were recently expressed at high levels inside Pichia pastoris cells. Based on …

Single dose adenovirus vectored vaccine induces a potent and long-lasting immune response against rabbit hemorrhagic disease virus after parenteral or mucosal …

E Fernández, JR Toledo, M Chiong, F Parra… - Veterinary immunology …, 2011 - Elsevier
Rabbit hemorrhagic disease virus (RHDV) is the etiological agent of a lethal and contagious
disease of rabbits that remains as a serious problem worldwide. As this virus does not …

Protective immune responses in rabbits induced by a suicidal DNA vaccine of the VP60 gene of rabbit hemorrhagic disease virus

Y Cheng, Z Chen, C Li, C Meng, R Wu, G Liu - Antiviral research, 2013 - Elsevier
A suicidal DNA vaccine based on a Semliki Forest virus (SFV) replicon was evaluated for the
development of a vaccine against rabbit hemorrhagic disease virus (RHDV). The VP60 gene …

Rabbit hemorrhagic disease virus VP60 protein expressed in recombinant swinepox virus self-assembles into virus-like particles with strong immunogenicity in rabbits

C Liu, M Lin, H Hu, X Liu, Y Bian, X Huang… - Frontiers in …, 2022 - frontiersin.org
Rabbit Hemorrhagic Disease (RHD) is an economically significant infectious disease of
rabbits, and its infection causes severe losses in the meat and fur industry. RHD Virus …