The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …

Neurodegenerative diseases selectively target subpopulations of neurons, leading to the
progressive failure of defined brain systems, but the basis of such selective neuronal …

Animal models of Parkinson's disease (PD) have been widely used in the past four decades
to investigate the pathogenesis and pathophysiology of this neurodegenerative disorder …

Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Parkinson's disease is one of the most common neurodegenerative diseases. Animal
models have contributed a large part to our understanding and therapeutics developed for …

Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

The clearance of damaged or dysfunctional mitochondria by selective autophagy
(mitophagy) is important for cellular homeostasis and prevention of disease. Our …

Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and
amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of
inherited Parkinson's disease. Little is known about its involvement in the pathogenesis of …

The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the
study of developmental biology and gene function. It also has proven to be a valuable model …