Improving fine-map** by modeling infinitesimal effects
Fine-map** aims to identify causal genetic variants for phenotypes. Bayesian fine-
map** algorithms (for example, SuSiE, FINEMAP, ABF and COJO-ABF) are widely used …
map** algorithms (for example, SuSiE, FINEMAP, ABF and COJO-ABF) are widely used …
TWAS-GKF: a novel method for causal gene identification in transcriptome-wide association studies with knockoff inference
Motivation Transcriptome-wide association study (TWAS) aims to identify trait-associated
genes regulated by significant variants to explore the underlying biological mechanisms at a …
genes regulated by significant variants to explore the underlying biological mechanisms at a …
A Statistical View of Column Subset Selection
We consider the problem of selecting a small subset of representative variables from a large
dataset. In the computer science literature, this dimensionality reduction problem is typically …
dataset. In the computer science literature, this dimensionality reduction problem is typically …
Second-order group knockoffs with applications to GWAS
Conditional testing via the knockoff framework allows one to identify--among large number
of possible explanatory variables--those that carry unique information about an outcome of …
of possible explanatory variables--those that carry unique information about an outcome of …
KnockoffHybrid: A knockoff framework for hybrid analysis of trio and population designs in genome-wide association studies
Both trio and population designs are popular study designs for identifying risk genetic
variants in genome-wide association studies (GWASs). The trio design, as a family-based …
variants in genome-wide association studies (GWASs). The trio design, as a family-based …
Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating
Local genetic correlation analysis is an important tool for identifying genetic loci with shared
biology across traits. Recently, Border et al. have shown that the results of these analyses …
biology across traits. Recently, Border et al. have shown that the results of these analyses …
Second-order group knockoffs with applications to genome-wide association studies
Motivation Conditional testing via the knockoff framework allows one to identify—among a
large number of possible explanatory variables—those that carry unique information about …
large number of possible explanatory variables—those that carry unique information about …
Pinpointing Important Genetic Variants via A Feature-level Filter and Group Knockoffs
J Gu, Z Chen, Z He - arxiv preprint arxiv:2408.12618, 2024 - arxiv.org
Identifying variants that carry substantial information on the trait of interest remains a core
topic in genetic studies. In analyzing the EADB-UKBB dataset to identify genetic variants …
topic in genetic studies. In analyzing the EADB-UKBB dataset to identify genetic variants …
Knoop: practical enhancement of knockoff with over-parameterization for variable selection
Variable selection plays a crucial role in enhancing modeling effectiveness across diverse
fields, addressing the challenges posed by high-dimensional datasets of correlated …
fields, addressing the challenges posed by high-dimensional datasets of correlated …
[HTML][HTML] Controlled Variable Selection from Summary Statistics Only? A Solution via GhostKnockoffs and Penalized Regression
Identifying which variables do influence a response while controlling false positives
pervades statistics and data science. In this paper, we consider a scenario in which we only …
pervades statistics and data science. In this paper, we consider a scenario in which we only …