Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide.
Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming …

Glucose is a crucial molecule in energy production and produces different end products in
non-tumourigenic-and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose …

An important pathophysiological process of acute kidney injury (AKI) is mitochondrial
fragmentation in renal tubular epithelial cells, which leads to cell death. Pyruvate kinase M2 …

Cardiac metabolism plays a crucial role in producing sufficient energy to sustain cardiac
function. However, the role of metabolism in different aspects of cardiomyocyte regeneration …

Cancer is a leading cause of death globally. Cancer cell transformation is the result of
intricate crosstalk between intracellular components and proteins. A characteristic feature of …

Mitochondrial metabolism, dynamics, and stress responses in the intestinal stem cell niche
play a pivotal role in regulating intestinal epithelial cell homeostasis, including self-renewal …

Many types of differentiated cells can reenter the cell cycle upon injury or stress. The
underlying mechanisms are still poorly understood. Here, we investigated how quiescent …

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes.
The main pathological changes were intestinal mucosal injury. Leucine-rich repeat …

Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to
explore the mechanistic basis of cancer-related inflammation, providing important evidence …

The increased resistance and toxicity have become the main causes of chemotherapy
failure for treating lung cancer. The combination of chemotherapeutic drugs with other …