Current state and challenges in develo** oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

A Banerjee, J Qi, R Gogoi, J Wong… - Journal of Controlled …, 2016 - Elsevier
Nanoparticles find intriguing applications in oral drug delivery since they present a large
surface area for interactions with the gastrointestinal tract and can be modified in various …

[HTML][HTML] Multi-endpoint toxicological assessment of polystyrene nano-and microparticles in different biological models in vitro

M Hesler, L Aengenheister, B Ellinger, R Drexel… - Toxicology in Vitro, 2019 - Elsevier
Nanoplastics (NP) and microplastics (MP) accumulate in our environment as a consequence
of the massive consumption of plastics. Huge knowledge-gaps exist regarding uptake and …

[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

P Lundquist, P Artursson - Advanced drug delivery reviews, 2016 - Elsevier
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …

Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation

RFS Gonçalves, JT Martins, CMM Duarte… - Trends in Food Science …, 2018 - Elsevier
Background Aiming at the enhancement of food products' nutritional and health value, the
incorporation of nutraceuticals has attracted increasing interest in the last years. However …

Distinct accumulation of nanoplastics in human intestinal organoids

Z Hou, R Meng, G Chen, T Lai, R Qing, S Hao… - Science of The Total …, 2022 - Elsevier
Plastic particles, especially nanoplastics, represent an emerging concern of threat to human
health, oral uptake is an important pathway for the plastic particles ingestion by human …

Solid lipid nanoparticles for enhanced oral absorption: A review

E Salah, MM Abouelfetouh, Y Pan, D Chen… - colloids and surfaces B …, 2020 - Elsevier
Recent trends in nanoparticles-based oral therapy have led to a proliferation of studies to
enhance solubility, permeability and chemical stability of many drugs. One of the significant …

[HTML][HTML] Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

V Francia, D Montizaan… - Beilstein journal of …, 2020 - beilstein-journals.org
Nano-sized materials have great potential as drug carriers for nanomedicine applications.
Thanks to their size, they can exploit the cellular machinery to enter cells and be trafficked …