Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends

Q Sun, Z Hong, C Zhang, L Wang, Z Han… - Signal transduction and …, 2023 - nature.com
Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy

S Peng, F **ao, M Chen, H Gao - Advanced Science, 2022 - Wiley Online Library
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …

[HTML][HTML] Peptide-based nanomaterials: Self-assembly, properties and applications

T Li, XM Lu, MR Zhang, K Hu, Z Li - Bioactive Materials, 2022 - Elsevier
Peptide-based materials that have diverse structures and functionalities are an important
type of biomaterials. In former times, peptide-based nanomaterials with excellent stability …

Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy

Y Zhou, Q Li, Y Wu, X Li, Y Zhou, Z Wang, H Liang… - ACS …, 2023 - ACS Publications
Self-assembly has emerged as an extensively used method for constructing biomaterials
with sizes ranging from nanometers to micrometers. Peptides have been extensively …

Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2, 3-dioxygenase-blockade tumor immunotherapy

L Dai, M Yao, Z Fu, X Li, X Zheng, S Meng… - Nature …, 2022 - nature.com
Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

JD Martin, H Cabral, T Stylianopoulos… - Nature reviews Clinical …, 2020 - nature.com
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy

P Tiwari, K Yadav, RP Shukla, S Gautam… - Journal of Controlled …, 2023 - Elsevier
Nanovesicles and bio-vesicles (BVs) have emerged as promising tools to achieve targeted
cancer therapy due to their ability to overcome many of the key challenges currently being …

Second near‐infrared photothermal semiconducting polymer nanoadjuvant for enhanced cancer immunotherapy

J Li, X Yu, Y Jiang, S He, Y Zhang, Y Luo… - Advanced …, 2021 - Wiley Online Library
Immunotherapy has offered new treatment options for cancer; however, the therapeutic
benefits are often modest and desired to be improved. A semiconducting polymer …

Tumor microenvironment‐activatable prodrug vesicles for nanoenabled cancer chemoimmunotherapy combining immunogenic cell death induction and CD47 …

F Zhou, B Feng, H Yu, D Wang, T Wang… - Advanced …, 2019 - Wiley Online Library
Chemoimmunotherapy is reported to activate a robust T cell antitumor immune response by
triggering immunogenic cell death (ICD), which has initiated a number of clinical trials …

Combining nanomedicine and immunotherapy

Y Shi, T Lammers - Accounts of chemical research, 2019 - ACS Publications
Conspectus Nanomedicine holds significant potential to improve the efficacy of cancer
immunotherapy. Thus far, nanomedicines, ie, 1–100 (0) nm sized drug delivery systems …