B cells in autoimmune and neurodegenerative central nervous system diseases
B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …
[HTML][HTML] Smouldering lesion in MS: microglia, lymphocytes and pathobiochemical mechanisms
Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …
neurodegenerative disease of the central nervous system (CNS). Immune cell infiltration can …
B‐cell Therapy for Multiple Sclerosis: Entering an era
AL Greenfield, SL Hauser - Annals of neurology, 2018 - Wiley Online Library
Monoclonal antibodies that target CD20 expressing B cells represent an important new
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells
B cells have paradoxical roles in autoimmunity, exerting both pathogenic and protective
effects. Pathogenesis may be antibody independent, as B cell depletion therapy (BCDT) …
effects. Pathogenesis may be antibody independent, as B cell depletion therapy (BCDT) …
A gradient of neuronal loss and meningeal inflammation in multiple sclerosis
R Magliozzi, OW Howell, C Reeves… - Annals of …, 2010 - Wiley Online Library
Objective Prominent inflammation with formation of ectopic B‐cell follicle‐like structures in
the meninges in secondary progressive multiple sclerosis (MS)(SPMS) is associated with …
the meninges in secondary progressive multiple sclerosis (MS)(SPMS) is associated with …
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …
including recent insights into its molecular neuropathology and immunology. It shows that all …
Abnormal B‐cell cytokine responses a trigger of T‐cell–mediated disease in MS?
A Bar‐Or, L Fawaz, B Fan, PJ Darlington… - Annals of …, 2010 - Wiley Online Library
Objective To study antibody‐independent contributions of B cells to inflammatory disease
activity, and the immune consequences of B‐cell depletion with rituximab, in patients with …
activity, and the immune consequences of B‐cell depletion with rituximab, in patients with …
Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins
SM Brändle, B Obermeier, M Senel, J Bruder… - Proceedings of the …, 2016 - pnas.org
Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis
(MS), a disabling inflammatory disease of the central nervous system (CNS). OCBs are …
(MS), a disabling inflammatory disease of the central nervous system (CNS). OCBs are …
Pathogenic autoantibodies in multiple sclerosis—from a simple idea to a complex concept
The role of autoantibodies in multiple sclerosis (MS) has been enigmatic since the first
description, many decades ago, of intrathecal immunoglobulin production in people with this …
description, many decades ago, of intrathecal immunoglobulin production in people with this …