Therapeutic anticoagulation is indicated for a variety of circumstances and conditions in
several fields of medicine to prevent or treat venous and arterial thromboembolism …

Thrombosis is a major complication of cardiovascular disease, leading to myocardial
infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a …

Background & Aims Portal vein thrombosis (PVT) is a relatively frequent event in patients
with cirrhosis. While different risk factors for PVT have been reported, such as decreased …

Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role
of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review …

Red blood cells (RBCs) have historically been considered passive bystanders in
thrombosis. However, clinical and epidemiological studies have associated quantitative and …

Since its discovery over 350 years ago, studies of fibrinogen have revealed remarkable
characteristics. Its complex structure as a large (340 kD a) hexameric homodimer supports …

Venous thromboembolism (VTE) encompasses deep-vein thrombosis (DVT) and pulmonary
embolism. VTE is the leading cause of lost disability-adjusted life years and the third leading …

While hemostasis is the physiological process that prevents blood loss after vessel injury,
thrombosis is often portrayed as a pathologic event involving blood coagulation and platelet …

Fibrinolysis appears in many diverse physiological situations, and the components of the
system are well established, along with mechanistic details for the individual reactions and …