Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Simple Summary The dysregulation of ACSL3 and ACSL4, which belong to the long-chain
fatty acyl CoA synthetase family (ACSLs), affects the behavior of various cancer cells. This …

Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-
resistant cancers, including metastatic castration-resistant prostate cancer, and predicts poor …

Metabolic reprogramming is one of the most important hallmarks of malignant tumors.
Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and …

Background Recent evidence shows that inducing ferroptosis may improve efficacy of tumor
therapy. However, ferroptosis-related genes have been little studied in patients with breast …

Pressure overload–induced cardiac hypertrophy is a common cause of heart failure (HF),
and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on …

Ferroptosis is a novel type of programmed cell death that differs from apoptosis in that it
involves iron-dependent peroxidation of membrane phospholipids. Its role in a variety of …

Lipids, as one of the three primary energy sources, provide energy for all cellular life
activities. Lipids are also known to be involved in the formation of cell membranes and play …

Cancer is a major public health problem around the world and the key leading cause of
death in the world. It is well-known that glucolipid metabolism, immunoreaction, and …

Genetics, age, environmental factors, and oxidative stress have all been implicated in the
development of Parkinson's disease (PD); however, a complete understanding of its …