The mammalian circadian clock relies on the transcription factor CLOCK: BMAL1 to
coordinate the rhythmic expression of thousands of genes. Consistent with the various …

Abstract Recently, microRNAs (miRNA), small noncoding RNAs, have taken center stage in
the field of human molecular oncology. However, their roles in tumor biology remain largely …

Gene expression is directly controlled by transcription factors (TFs) in a complex
combination manner. It remains a challenging task to systematically infer how the …

The seed is the pharmaceutical and breeding organ of Cassia obtusifolia, a well-known
medical herb containing aurantio-obtusin (a kind of anthraquinone), food, and landscape. In …

Adipogenesis is a multi-step process orchestrated by activation of numerous TFs, whose
cooperation and regulatory network remain elusive. Activating transcription factor 4 (ATF4) is …

Cytochrome P450 2C19 (CYP2C19) is involved in the metabolism of several drugs that are
currently in clinical use. The gene encoding CYP2C19 is polymorphic with the existence of …

Background Interactions among transcription factors (TFs) and histone modifications (HMs)
play an important role in the precise regulation of gene expression. The context specificity of …

Transcription factors (TFs) are a special class of DNA-binding proteins that orchestrate gene
transcription by recruiting other TFs, co-activators or co-repressors. Their combinatorial …

Plants are exposed to a variety of environmental conditions, and their ability to respond to
environmental variation depends on the proper regulation of gene expression in an organ …

Abstract Background Transcription factors (TFs) are important regulatory proteins that
govern transcriptional regulation. Today, it is known that in higher organisms different TFs …