The promise of precision medicine in rheumatology
Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …
clinical presentation, disease course, and treatment response. Therefore, precision …
Psoriatic arthritis
Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical
features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or …
features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or …
Precision medicine: the precision gap in rheumatic disease
CMA Lin, FAH Cooles, JD Isaacs - Nature Reviews Rheumatology, 2022 - nature.com
For many oncological conditions, the application of timely and patient-tailored targeted
therapies, or precision medicine, is a major therapeutic development that has provided …
therapies, or precision medicine, is a major therapeutic development that has provided …
Impact of pretreatment systemic inflammatory markers on treatment persistence with biologics and conventional systemic therapy: a retrospective study of patients with …
E Sugimoto, H Matsuda, S Shibata, Y Mizuno… - Journal of Clinical …, 2023 - mdpi.com
Systemic inflammation plays a central role in the pathophysiology of psoriasis. This study
examined accessible systemic inflammatory markers in patients with psoriasis vulgaris and …
examined accessible systemic inflammatory markers in patients with psoriasis vulgaris and …
Phenotypic heterogeneity in psoriatic arthritis: towards tissue pathology-based therapy
A Najm, CS Goodyear, IB McInnes… - Nature Reviews …, 2023 - nature.com
Psoriatic arthritis (PsA) is a heterogeneous disease involving multiple potential tissue
domains. Most outcome measures used so far in randomized clinical trials do not sufficiently …
domains. Most outcome measures used so far in randomized clinical trials do not sufficiently …
Pathogenesis of psoriatic arthritis
C Stober - Best Practice & Research Clinical Rheumatology, 2021 - Elsevier
Psoriatic arthritis (PsA) is a heterogenous systemic inflammatory disorder which affects
peripheral joints (PsA) and skin (psoriasis (Ps)), but also causes inflammation at entheseal …
peripheral joints (PsA) and skin (psoriasis (Ps)), but also causes inflammation at entheseal …
The bone marrow side of axial spondyloarthritis
Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …
Insulin resistance impairs biologic agent response in moderate-to-severe plaque psoriasis: insights from a prospective cohort study in China
D Huang, X Zhong, Y Jiang, L Kong… - British Journal of …, 2024 - academic.oup.com
Background Psoriasis and insulin resistance (IR) are closely related, but it remains unclear
whether IR affects the treatment of patients with psoriasis. Objective To investigate whether …
whether IR affects the treatment of patients with psoriasis. Objective To investigate whether …
Soluble biomarkers for diagnosis, monitoring, and therapeutic response assessment in psoriasis
Background Psoriasis is an inflammatory disease associated with multiple comorbidities.
Biomarkers for the assessment of psoriasis, its associated comorbidities, and the therapeutic …
Biomarkers for the assessment of psoriasis, its associated comorbidities, and the therapeutic …
Management of concomitant inflammatory bowel disease or uveitis in patients with psoriatic arthritis: an updated review informing the 2021 GRAPPA treatment …
Objective Several advanced therapies have been licensed across the related conditions of
psoriatic arthritis (PsA), Crohn disease (CD), ulcerative colitis (UC), and noninfectious …
psoriatic arthritis (PsA), Crohn disease (CD), ulcerative colitis (UC), and noninfectious …