The promise of precision medicine in rheumatology

JM Guthridge, CA Wagner, JA James - Nature medicine, 2022 - nature.com
Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Psoriatic arthritis

O FitzGerald, A Ogdie, V Chandran… - Nature reviews Disease …, 2021 - nature.com
Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical
features, which complicates psoriasis in 30% of patients. There are no diagnostic criteria or …

Precision medicine: the precision gap in rheumatic disease

CMA Lin, FAH Cooles, JD Isaacs - Nature Reviews Rheumatology, 2022 - nature.com
For many oncological conditions, the application of timely and patient-tailored targeted
therapies, or precision medicine, is a major therapeutic development that has provided …

Impact of pretreatment systemic inflammatory markers on treatment persistence with biologics and conventional systemic therapy: a retrospective study of patients with …

E Sugimoto, H Matsuda, S Shibata, Y Mizuno… - Journal of Clinical …, 2023 - mdpi.com
Systemic inflammation plays a central role in the pathophysiology of psoriasis. This study
examined accessible systemic inflammatory markers in patients with psoriasis vulgaris and …

Phenotypic heterogeneity in psoriatic arthritis: towards tissue pathology-based therapy

A Najm, CS Goodyear, IB McInnes… - Nature Reviews …, 2023 - nature.com
Psoriatic arthritis (PsA) is a heterogeneous disease involving multiple potential tissue
domains. Most outcome measures used so far in randomized clinical trials do not sufficiently …

Pathogenesis of psoriatic arthritis

C Stober - Best Practice & Research Clinical Rheumatology, 2021 - Elsevier
Psoriatic arthritis (PsA) is a heterogenous systemic inflammatory disorder which affects
peripheral joints (PsA) and skin (psoriasis (Ps)), but also causes inflammation at entheseal …

The bone marrow side of axial spondyloarthritis

D Mauro, S Gandolfo, E Tirri, G Schett… - Nature Reviews …, 2023 - nature.com
Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …

Insulin resistance impairs biologic agent response in moderate-to-severe plaque psoriasis: insights from a prospective cohort study in China

D Huang, X Zhong, Y Jiang, L Kong… - British Journal of …, 2024 - academic.oup.com
Background Psoriasis and insulin resistance (IR) are closely related, but it remains unclear
whether IR affects the treatment of patients with psoriasis. Objective To investigate whether …

Soluble biomarkers for diagnosis, monitoring, and therapeutic response assessment in psoriasis

MR Pourani, F Abdollahimajd, O Zargari… - Journal of …, 2022 - Taylor & Francis
Background Psoriasis is an inflammatory disease associated with multiple comorbidities.
Biomarkers for the assessment of psoriasis, its associated comorbidities, and the therapeutic …

Management of concomitant inflammatory bowel disease or uveitis in patients with psoriatic arthritis: an updated review informing the 2021 GRAPPA treatment …

DR Jadon, DA van der Windt, LC Coates… - The Journal of …, 2023 - jrheum.org
Objective Several advanced therapies have been licensed across the related conditions of
psoriatic arthritis (PsA), Crohn disease (CD), ulcerative colitis (UC), and noninfectious …