Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies

K Mantzarlis, V Tsolaki… - Oxidative medicine and …, 2017 - Wiley Online Library
Sepsis is one of the most important causes of death in intensive care units. Despite the fact
that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and …

The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities

Z Huang, AH Rose, PR Hoffmann - Antioxidants & redox signaling, 2012 - liebertpub.com
Abstract Dietary selenium (] Se), mainly through its incorporation into selenoproteins, plays
an important role in inflammation and immunity. Adequate levels of Se are important for …

Selenium in human health and disease

SJ Fairweather-Tait, Y Bao, MR Broadley… - Antioxidants & redox …, 2011 - liebertpub.com
This review covers current knowledge of selenium in the environment, dietary intakes,
metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant …

Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy

CA Prauchner - Burns, 2017 - Elsevier
Sepsis is one of the main causes of death among critically ill patients. Sepsis pathogenesis
includes infection by gram-negative and gram-positive bacteria, fungi, or both; exacerbated …

Antioxidant vitamins and trace elements in critical illness

WAC Koekkoek, ARH van Zanten - Nutrition in clinical practice, 2016 - Wiley Online Library
This comprehensive narrative review summarizes relevant antioxidant mechanisms, the
antioxidant status, and effects of supplementation in critically ill patients for the most studied …

Mild heat-assisted polydopamine/alginate hydrogel containing low-dose nanoselenium for facilitating infected wound healing

J Xu, MR Younis, Z Zhang, Y Feng, L Su… - … Applied Materials & …, 2023 - ACS Publications
In clinical practice, it has become urgent to develop multifunctional wound dressings that
can combat infection and prompt wound healing simultaneously. In this study, we proposed …

[HTML][HTML] Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence

E Wesselink, WAC Koekkoek, S Grefte, RF Witkamp… - Clinical Nutrition, 2019 - Elsevier
Persistent physical impairment is frequently encountered after critical illness. Recent data
point towards mitochondrial dysfunction as an important determinant of this phenomenon …

Association between fatality rate of COVID-19 and selenium deficiency in China

HY Zhang, AR Zhang, QB Lu, XA Zhang… - BMC infectious …, 2021 - Springer
Background COVID-19 has impacted populations around the world, with the fatality rate
varying dramatically across countries. Selenium, as one of the important micronutrients …

Glutamine and glutathione at ICU admission in relation to outcome

PC Rodas, O Rooyackers, C Hebert, Å Norberg… - Clinical …, 2012 - portlandpress.com
Glutamine depletion is demonstrated to be an independent predictor of hospital mortality in
ICU (intensive care unit) patients. Today glutamine supplementation is recommended to ICU …

[HTML][HTML] Clinical significance of micronutrient supplementation in critically ill COVID-19 patients with severe ARDS

Q Notz, J Herrmann, T Schlesinger, P Helmer… - Nutrients, 2021 - mdpi.com
The interplay between inflammation and oxidative stress is a vicious circle, potentially
resulting in organ damage. Essential micronutrients such as selenium (Se) and zinc (Zn) …