Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …

Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Recent developments in lysosome biology have transformed our view of lysosomes from
static garbage disposals that can also act as suicide bags to decidedly dynamic multirole …

Infection of human macrophages with Salmonella enterica serovar Typhimurium (S.
Typhimurium) leads to inflammasome activation. Inflammasomes are multiprotein …

The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many
contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing" signal I" …

The receptors of the innate immune system detect specific microbial ligands to promote
effective inflammatory and adaptive immune responses. Although this idea is well …

Recent studies have demonstrated that, in addition to their central role in cellular catabolic
reactions, lysosomes are implicated in many cellular processes, including metabolism …

Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular
molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell …

Nucleotide‐binding oligomerization domain (NOD) and leucine‐rich repeat (LRR)‐
containing receptors or NOD‐like receptors (NLRs) are cytosolic pattern recognition …