Calcium signaling pathways control a variety of cellular events such as gene transcription,
protein phosphorylation, nucleotide metabolism, and ion transport. These pathways often …

Cardiac failure is one of the leading causes of mortality in developed countries. As life
expectancies of the populations of these countries grow, the number of patients suffering …

Dilated cardiomyopathy and hypertrophic cardiomyopathy (HCM) can be caused by
mutations in thin filament regulatory proteins of the contractile apparatus. In vitro functional …

To understand the molecular mechanisms whereby cardiomyopathy-related cardiac
troponin I (cTnI) mutations affect myofilament activity, we have investigated the Ca 2+ …

Muscle ultrastructure is characterised by a complex arrangement of many protein-protein
interactions. The sarcomere is the basic repeating unit of muscle, formed by two transverse …

Synthesizes the current knowledge in the field and provides new insights into medical
applications Metalloproteomics is the large-scale study of metal-binding proteins. These …

Cardiac troponin C (cTnC) is the Ca 2+-dependent switch for contraction in heart muscle
and a potential target for drugs in the therapy of heart failure. Ca 2+ binding to the regulatory …

Phosphorylation of the cardiac specific amino‐terminus of troponin I has been demonstrated
to reduce the Ca2+ affinity of the cardiac troponin C regulatory site. Recombinant N‐terminal …

Ca 2+ binding to cardiac troponin C (cTnC) triggers contraction in heart muscle. In heart
failure, myofilaments response to Ca 2+ are often altered and compounds that sensitize the …

Troponin I (TnI) is the inhibitory component of troponin, the ternary complex that regulates
skeletal and cardiac muscle contraction. Previous work showed that the C-terminal region of …