Comprehensive analysis of DNA methylation patterns is critical for understanding the
molecular basis of many human diseases. While hundreds of PCR-based DNA methylation …

The field of molecular biology is advancing fast with new powerful technologies, sequencing
methods and analysis software being developed constantly. Commonly used tools originally …

Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver
disease and the prevalence is rising, especially in women. Although during reproductive …

Defective placentation is the underlying cause of various pregnancy complications, such as
severe intrauterine growth restriction and preeclampsia. However, studies on human …

Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA
methylation, which is predominantly mediated by DNMT3A, a de novo DNA …

DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …

The developmental potential of human pluripotent stem cells suggests that they can produce
disease-relevant cell types for biomedical research. However, substantial variation has been …

Posttranslational histone modifications are important for gene regulation, yet the mode of
propagation and the contribution to heritable gene expression states remains controversial …

Summary Small RNAs associate with Argonaute proteins and serve as sequence-specific
guides for regulation of mRNA stability, productive translation, chromatin organization, and …

Epigenetic states and certain environmental responses in mammals and seed plants can
persist in the next sexual generation. These transgenerational effects have potential …