Ultrasound-assisted green synthesis of triazole-based azomethine/thiazolidin-4-one hybrid inhibitors for cancer therapy through targeting dysregulation signatures of …
AH Abdelmonsef, AM El-Saghier… - Green Chemistry Letters …, 2023 - Taylor & Francis
The overexpression of Rab proteins was linked to cancer development, making this family of
proteins an attractive drug target for the identification of novel inhibitors against tumor …
proteins an attractive drug target for the identification of novel inhibitors against tumor …
Thiazole-based thiosemicarbazones: Synthesis, cytotoxicity evaluation and molecular docking study
SM Gomha, HA Abdelhady, DZH Hassain… - Drug design …, 2021 - Taylor & Francis
Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …
Advancement of chimeric hybrid drugs to cure malaria infection: An overview with special emphasis on endoperoxide pharmacophores
Emergence and spread of Plasmodium falciparum resistant to artemisinin-based
combination therapy has led to a situation of haste in the scientific and pharmaceutical …
combination therapy has led to a situation of haste in the scientific and pharmaceutical …
Newly synthesized pyrazolinone chalcones as anticancer agents via inhibiting the PI3K/Akt/ERK1/2 signaling pathway
A series of novel pyrazolinone chalcones 3–9 have been synthesized through the
condensation of azo pyrazolinone derivatives with various aromatic aldehydes …
condensation of azo pyrazolinone derivatives with various aromatic aldehydes …
New amino acid Schiff bases as anticancer agents via potential mitochondrial complex I-associated hexokinase inhibition and targeting AMP-protein kinases/mTOR …
Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates
Background: Imidazo [2, 1-b] thiazole scaffolds were reported to possess various
pharmaceutical activities. Results: The novel compound named methyl-2-(1-(3-methyl-6-(p …
pharmaceutical activities. Results: The novel compound named methyl-2-(1-(3-methyl-6-(p …
Design, synthetic approach, in silico molecular docking and antibacterial activity of quinazolin-2, 4-dione hybrids bearing bioactive scaffolds
Antimicrobial resistance (AMR) is one of ten global public health threats facing humanity.
This created the need to identify and develop effective inhibitors as antimicrobial agents. In …
This created the need to identify and develop effective inhibitors as antimicrobial agents. In …
Cyclization of Chalcone Derivatives: Design, Synthesis, In Silico Docking Study, and Biological Evaluation of New Quinazolin-2,4-diones Incorporating Five-, Six …
Four novel series of quinazolin-2, 4-diones bearing five-, six-, and seven-membered
heterocyclic moieties 2–14 (such as pyrazole, oxazole, pyrimidine, and azepines) through …
heterocyclic moieties 2–14 (such as pyrazole, oxazole, pyrimidine, and azepines) through …
Synthesis, anticancer evaluation, computer-aided docking studies, and ADMET prediction of 1, 2, 3-triazolyl-pyridine hybrids as human aurora B kinase inhibitors
A novel series of 1, 2, 3-triazolyl-pyridine hybrids were prepared through the reaction of the
triazole derivative (1) with the appropriate aldehyde (2a–g) and malononitrile or ethyl …
triazole derivative (1) with the appropriate aldehyde (2a–g) and malononitrile or ethyl …
Synthesis, in silico and in vitro assessment of new quinazolinones as anticancer agents via potential AKT inhibition
A series of novel quinazolinone derivatives (2–13) was synthesized and examined for their
cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives …
cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these derivatives …