Colonization and Infection of Indwelling Medical Devices by Staphylococcus aureus with an Emphasis on Orthopedic Implants
The use of indwelling medical devices has constantly increased in recent years and has
revolutionized the quality of life of patients affected by different diseases. However, despite …
revolutionized the quality of life of patients affected by different diseases. However, despite …
Recent advances in iron chelation and gallium-based therapies for antibiotic resistant bacterial infections
V Vinuesa, MJ McConnell - International Journal of Molecular Sciences, 2021 - mdpi.com
Iron is essential for multiple bacterial processes and is thus required for host colonization
and infection. The antimicrobial activity of multiple iron chelators and gallium-based …
and infection. The antimicrobial activity of multiple iron chelators and gallium-based …
Iron metabolism at the interface between host and pathogen: from nutritional immunity to antibacterial development
Nutritional immunity is a form of innate immunity widespread in both vertebrates and
invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit …
invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit …
Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal …
Corynebacterium accolens is the predominant species of the healthy human nasal
microbiota, and its relative abundance is decreased in the context of chronic rhinosinusitis …
microbiota, and its relative abundance is decreased in the context of chronic rhinosinusitis …
A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity
Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in
biofilms that require high antibiotic concentrations. While oral drug delivery is frequently …
biofilms that require high antibiotic concentrations. While oral drug delivery is frequently …
Gallium as an Antibacterial Agent: A DFT/SMD Study of the Ga3+/Fe3+ Competition for Binding Bacterial Siderophores
The urgency of finding novel antibacterial drugs (not only antibiotics), exhibiting different
mechanisms of therapeutic action, is significant and has served as a premise for recognizing …
mechanisms of therapeutic action, is significant and has served as a premise for recognizing …
The combination of diethyldithiocarbamate and copper ions is active against Staphylococcus aureus and Staphylococcus epidermidis biofilms in vitro and in vivo
Staphylococcus aureus and Staphylococcus epidermidis are associated with life-threatening
infections. Despite the best medical care, these infections frequently occur due to antibiotic …
infections. Despite the best medical care, these infections frequently occur due to antibiotic …
Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in Staphylococcus aureus Small Colony Variants
Small colony variants (SCVs) of bacteria like Staphylococcus aureus are characterized by a
reduced colony size and are linked to increased antibiotic tolerance and resistance. Their …
reduced colony size and are linked to increased antibiotic tolerance and resistance. Their …
Recent drug-repurposing-driven advances in the discovery of novel antibiotics
Drug repurposing is a safe and successful pathway to speed up the novel drug discovery
and development processes compared with de novo drug discovery approaches. Drug …
and development processes compared with de novo drug discovery approaches. Drug …
Inhibition Mechanism of Methicillin-Resistant Staphylococcus aureus by Zinc Oxide Nanorods via Suppresses Penicillin-Binding Protein 2a
Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening infections. Zinc
oxide is well known as an effective antibacterial drug against many bacterial strains. We …
oxide is well known as an effective antibacterial drug against many bacterial strains. We …