Colonization and Infection of Indwelling Medical Devices by Staphylococcus aureus with an Emphasis on Orthopedic Implants

G Pietrocola, D Campoccia, C Motta… - International journal of …, 2022 - mdpi.com
The use of indwelling medical devices has constantly increased in recent years and has
revolutionized the quality of life of patients affected by different diseases. However, despite …

Recent advances in iron chelation and gallium-based therapies for antibiotic resistant bacterial infections

V Vinuesa, MJ McConnell - International Journal of Molecular Sciences, 2021 - mdpi.com
Iron is essential for multiple bacterial processes and is thus required for host colonization
and infection. The antimicrobial activity of multiple iron chelators and gallium-based …

Iron metabolism at the interface between host and pathogen: from nutritional immunity to antibacterial development

M Marchetti, O De Bei, S Bettati, B Campanini… - International journal of …, 2020 - mdpi.com
Nutritional immunity is a form of innate immunity widespread in both vertebrates and
invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit …

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal …

MA Menberu, S Liu, C Cooksley, AJ Hayes, AJ Psaltis… - Pathogens, 2021 - mdpi.com
Corynebacterium accolens is the predominant species of the healthy human nasal
microbiota, and its relative abundance is decreased in the context of chronic rhinosinusitis …

A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity

K Richter, N Thomas, J Claeys… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in
biofilms that require high antibiotic concentrations. While oral drug delivery is frequently …

Gallium as an Antibacterial Agent: A DFT/SMD Study of the Ga3+/Fe3+ Competition for Binding Bacterial Siderophores

N Kircheva, T Dudev - Inorganic Chemistry, 2020 - ACS Publications
The urgency of finding novel antibacterial drugs (not only antibiotics), exhibiting different
mechanisms of therapeutic action, is significant and has served as a premise for recognizing …

The combination of diethyldithiocarbamate and copper ions is active against Staphylococcus aureus and Staphylococcus epidermidis biofilms in vitro and in vivo

L Kaul, AI Abdo, T Coenye, BP Krom… - Frontiers in …, 2022 - frontiersin.org
Staphylococcus aureus and Staphylococcus epidermidis are associated with life-threatening
infections. Despite the best medical care, these infections frequently occur due to antibiotic …

Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in Staphylococcus aureus Small Colony Variants

K Richter, N Thomas, G Zhang, CA Prestidge… - Frontiers in cellular …, 2017 - frontiersin.org
Small colony variants (SCVs) of bacteria like Staphylococcus aureus are characterized by a
reduced colony size and are linked to increased antibiotic tolerance and resistance. Their …

Recent drug-repurposing-driven advances in the discovery of novel antibiotics

AK Konreddy, GU Rani, K Lee… - Current medicinal …, 2019 - ingentaconnect.com
Drug repurposing is a safe and successful pathway to speed up the novel drug discovery
and development processes compared with de novo drug discovery approaches. Drug …

Inhibition Mechanism of Methicillin-Resistant Staphylococcus aureus by Zinc Oxide Nanorods via Suppresses Penicillin-Binding Protein 2a

A Hassan, FA Al-Salmi, MA Saleh, JM Sabatier… - ACS …, 2023 - ACS Publications
Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening infections. Zinc
oxide is well known as an effective antibacterial drug against many bacterial strains. We …