A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

H Kadry, B Noorani, L Cucullo - Fluids and Barriers of the CNS, 2020 - Springer
The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

[HTML][HTML] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium

F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong… - Cell stem cell, 2020 - cell.com
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …

The glymphatic system: a beginner's guide

NA Jessen, ASF Munk, I Lundgaard… - Neurochemical …, 2015 - Springer
The glymphatic system is a recently discovered macroscopic waste clearance system that
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …

The structure and function of the Na, K-ATPase isoforms in health and disease

MV Clausen, F Hilbers, H Poulsen - Frontiers in physiology, 2017 - frontiersin.org
The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

Choroid plexus and the blood–cerebrospinal fluid barrier in disease

P Solár, A Zamani, L Kubíčková, P Dubový… - Fluids and Barriers of the …, 2020 - Springer
The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the
least studied structures of the central nervous system (CNS) despite its clinical importance …

Development and functions of the choroid plexus–cerebrospinal fluid system

MP Lun, ES Monuki, MK Lehtinen - Nature Reviews Neuroscience, 2015 - nature.com
The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …

Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

A new look at cerebrospinal fluid circulation

T Brinker, E Stopa, J Morrison, P Klinge - Fluids and Barriers of the CNS, 2014 - Springer
According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the
majority of CSF is produced by the choroid plexus, circulates through the ventricles, the …

Anatomy and physiology of the cerebrospinal fluid

D Fleischman, J Berdahl - Ocular Fluid Dynamics: Anatomy, Physiology …, 2019 - Springer
The cerebrospinal fluid (CSF) is the primary circulating fluid of the central nervous system. It
serves numerous important physiologic and maintenance functions, and its production and …