Image-based profiling for drug discovery: due for a machine-learning upgrade?
Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …
biological images is reduced to a multidimensional profile, a collection of extracted image …
Critical assessment of AI in drug discovery
ABSTRACT Introduction: Artificial Intelligence (AI) has become a component of our everyday
lives, with applications ranging from recommendations on what to buy to the analysis of …
lives, with applications ranging from recommendations on what to buy to the analysis of …
Morphological profiling of small molecules
S Ziegler, S Sievers, H Waldmann - Cell chemical biology, 2021 - cell.com
Profiling approaches such as gene expression or proteome profiling generate small-
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …
Phenotypic profiling of reference chemicals across biologically diverse cell types using the cell painting assay
Cell Painting is a high-throughput phenotypic profiling assay that uses fluorescent
cytochemistry to visualize a variety of organelles and high-content imaging to derive a large …
cytochemistry to visualize a variety of organelles and high-content imaging to derive a large …
A phenomics approach for antiviral drug discovery
Background The emergence and continued global spread of the current COVID-19
pandemic has highlighted the need for methods to identify novel or repurposed therapeutic …
pandemic has highlighted the need for methods to identify novel or repurposed therapeutic …
Pharmacogenomics of breast cancer: highlighting CYP2D6 and tamoxifen
Purpose To review recent pharmacogenomics studies on breast cancer patients undergoing
tamoxifen therapy, highlighting how our knowledge on cytochrome P450 2D6 (CYP2D6) can …
tamoxifen therapy, highlighting how our knowledge on cytochrome P450 2D6 (CYP2D6) can …
Eco-friendly synthesis of new olanzapine derivatives and evaluation of their anticancer potential
New derivatives of the known antipsychotic drug olanzapine have been obtained as
potential compounds with anticancer activity in two metabolically different breast cancer cell …
potential compounds with anticancer activity in two metabolically different breast cancer cell …
Selection of optimal cell lines for high-content phenotypic screening
High-content microscopy offers a scalable approach to screen against multiple targets in a
single pass. Prior work has focused on methods to select “optimal” cellular readouts in …
single pass. Prior work has focused on methods to select “optimal” cellular readouts in …
In vitro predictions of acute fish toxicity for development of sustainable crop protection products
T Lunsman, G Harwood, A Lehman… - Journal of Agricultural …, 2024 - ACS Publications
New agrochemicals must demonstrate safety to numerous ecological systems, including
aquatic systems, and aquatic vertebrate toxicity is typically evaluated by using the in vivo …
aquatic systems, and aquatic vertebrate toxicity is typically evaluated by using the in vivo …
[HTML][HTML] Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
Environmental chemicals are commonly studied one at a time, and there is a need to
advance our understanding of the effect of exposure to their combinations. Here we apply …
advance our understanding of the effect of exposure to their combinations. Here we apply …