Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Reactive oxygen species (ROS) are increasingly recognized as critical determinants of
cellular signaling and a strict balance of ROS levels must be maintained to ensure proper …

Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

Gastric cancer (GC) is a highly malignant disease affecting humans worldwide and has a
poor prognosis. Most GC cases are detected at advanced stages due to the cancer lacking …

Background Identification and treatment in the early stage can significantly improve the
prognosis of gastric cancer (GC). However, to date, there is still no ideal biomarker that can …

Background Due to high mortality and lack of efficient screening, new tools for ovarian
cancer (OC) diagnosis are urgently needed. To broaden the knowledge on the pathological …

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry is used to detect
intact whole exosomes, yielding exosomal fingerprints within minutes. This rapid exosome …

Background Gastric cancer (GC) is one of the most lethal forms of cancer due to the absence
of tools for its early detection. Here, we explored critical biomarkers for early diagnosis …

Blood vessels are the most important way for cancer cells to survive and diffuse in the body,
metastasizing distant organs. During the process of tumor expansion, the neoplastic mass …