Carnitine is essential for the transfer of long-chain fatty acids across the inner mitochondrial
membrane for subsequent β-oxidation. It can be synthesized by the body or assumed with …

Intracellular and extracellular interactions with proteins enables the functional and
mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described …

Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease
(CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both …

Lipids are vital components of many biological processes and crucial in the pathogenesis of
numerous common diseases, but the specific mechanisms coupling intracellular lipids to …

Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and
macrophages, and integrates inflammatory and metabolic responses. Studies in aP2 …

Abstract Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for
early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in …