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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
Long noncoding RNAs in cancer metastasis
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …
multistep process that occurs through the acquisition of molecular and phenotypic changes …
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
Tumor immune microenvironment lncRNAs
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …
immune responses. The nature of their cell type-specific gene expression and other …
Emerging roles of lncRNA in cancer and therapeutic opportunities
MC Jiang, JJ Ni, WY Cui, BY Wang… - American journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Cancer is difficult to cure due to frequent metastasis, and develo** effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …
Weyl and Dirac semimetals in three-dimensional solids
Weyl and Dirac semimetals are three-dimensional phases of matter with gapless electronic
excitations that are protected by topology and symmetry. As three-dimensional analogs of …
excitations that are protected by topology and symmetry. As three-dimensional analogs of …
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the
third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in …
third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in …
NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death
D Huang, J Chen, L Yang, Q Ouyang, J Li, L Lao… - Nature …, 2018 - nature.com
Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to
escape immunological destruction. We demonstrated that tumor-specific cytotoxic T …
escape immunological destruction. We demonstrated that tumor-specific cytotoxic T …
Valley-dependent properties of monolayer , and
In a recent work, new two-dimensional materials, monolayer MoSi 2 N 4 and WSi 2 N 4,
were successfully synthesized in experiment, and several other monolayer materials with a …
were successfully synthesized in experiment, and several other monolayer materials with a …