Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of
immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex …

The current therapeutic antibody market in the US consists of 100 antibody-based products
and their market value is expected to explode beyond $300 billion by 2025. These therapies …

Background Induced regulatory T cells (iTregs) are a heterogeneous population of
immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity …

Simple Summary Adoptive immunotherapy has emerged as an effective alternative of
mounting impact to the current standard of care in cancer, viral infections, and recently …

There is significant potential in exploiting antibody specificity to develop new therapeutic
treatments. However, intracellular protein delivery is a paramount challenge because of the …

Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development,
maturation, and function of regulatory T cells (Tregs). The FoxP3 pre-mRNA is subject to …

Simple Summary This review aims to analyze the clinical drawbacks faced by PKC inhibitors
and uncovering aspects that might potentially interfere with the clinical outcome of …

T cell receptor signaling, together with cytokine-induced signals, can differentially regulate
RNA processing to influence T helper versus regulatory T cell fate. Protein kinase C family …