Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

Endoplasmic reticulum (ER) stress is a common feature of several physiological and
pathological conditions affecting the function of the secretory pathway. To restore ER …

Stress induced by accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a
classic feature of secretory cells and is observed in many tissues in human diseases …

Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that
play a critical role in the pathophysiology of stroke. ER stress occurs when …

Significant attention has recently been drawn to the potential link between head trauma and
the development of neurodegenerative disease, namely chronic traumatic encephalopathy …

Because proliferative vitreoretinopathy cannot be effectively treated, its prevention is
indispensable for the success of surgery for retinal detachment. The elaboration of …

In this study, we investigated the development of endoplasmic reticulum (ER) stress after
traumatic brain injury (TBI) and the efficacy of post-TBI administration of docosahexaenoic …

Endoplasmic reticulum (ER) stress has been linked with various acute and chronic
neurodegenerative diseases. We previously found that optic nerve (ON) injury and diseases …

Background The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that
mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized …

The control of apoptosis in mammals has been historically associated with the activity of the
BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death …