Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications

G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Dietary nutrient deficiencies and risk of depression (Review Article 2018–2023)

M Zielińska, E Łuszczki, K Dereń - Nutrients, 2023 - mdpi.com
Depression is classified as one of the most common mental disorders. Its prevalence has
recently increased, becoming a growing public health threat. This review focuses on …

[HTML][HTML] Chrysin protects against cerebral ischemia-reperfusion injury in hippocampus via restraining oxidative stress and transition elements

J Shang, J Jiao, M Yan, J Wang, Q Li… - Biomedicine & …, 2023 - Elsevier
Chrysin is a natural flavonoid compound that has antioxidant and neuroprotective effects.
Cerebral ischemia reperfusion (CIR) is closely connected with increased oxidative stress in …

Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters

H You, B Lu - Biomolecules, 2023 - mdpi.com
The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding
exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that …

[HTML][HTML] Copper neurotoxicity: Induction of cognitive dysfunction: A review

D Feng, Y Zhao, W Li, X Li, J Wan, F Wang - Medicine, 2023 - journals.lww.com
Cognitive dysfunction occurs mainly in certain diseases and in the pathological process of
aging. In addition to this, it is also widespread in patients undergoing anesthesia, surgery …

Peptides derived from growth factors to treat Alzheimer's disease

S Gascon, J Jann, C Langlois-Blais, M Plourde… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
progressive neuron losses in memory-related brain structures. The classical features of AD …

Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro

M Fornaro, A Giovannelli, A Foggetti… - Neural regeneration …, 2020 - journals.lww.com
Neurotrophins play a major role in the regulation of neuronal growth such as neurite
sprouting or regeneration in response to nerve injuries. The role of nerve growth factor …

Drug delivery platforms for neonatal brain injury

R Narayanamurthy, JLJ Yang, JY Yager… - Journal of Controlled …, 2021 - Elsevier
Abstract Hypoxic-ischemic encephalopathy (HIE), initiated by the interruption of oxygenated
blood supply to the brain, is a leading cause of death and lifelong disability in newborns …

Metal ion coordination in peptide fragments of neurotrophins: A crucial step for understanding the role and signaling of these proteins in the brain

D La Mendola, G Arena, A Pietropaolo… - Coordination Chemistry …, 2021 - Elsevier
Some metal ions of the d-block are necessary for the proper growth, functioning and
maintenance of the central nervous system. In particular, copper and zinc ions have …

Greater circulating copper concentrations and copper/zinc ratios are associated with lower psychological distress, but not cognitive performance, in a sample of …

M Mravunac, EA Szymlek-Gay, R M. Daly, B R. Roberts… - Nutrients, 2019 - mdpi.com
Dyshomeostasis of copper and zinc is linked to neurodegeneration. This study investigated
the relationship between circulating copper and zinc and copper/zinc ratios and cognitive …