Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development

R De Alwis, S Chen, ES Gan, EE Ooi - EBioMedicine, 2020 - thelancet.com
The pandemic spread of a novel coronavirus–SARS coronavirus-2 (SARS-CoV-2) as a
cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of …

CpG oligonucleotides as vaccine adjuvants

N Kayraklioglu, B Horuluoglu, DM Klinman - DNA Vaccines: Methods and …, 2021 - Springer
CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides specifically
designed to stimulate Toll-like receptor 9. TLR9 is expressed on human plasmacytoid …

Built-in adjuvants for use in vaccines

Q Li, Z Li, N Deng, F Ding, Y Li, H Cai - European Journal of Medicinal …, 2022 - Elsevier
Vaccine refers to biological products that are produced using various pathogenic
microorganisms for inoculation. The goal of vaccination is to induce a robust immune …

Expression of codon-optimized PDCoV-RBD protein in baculovirus expression system and immunogenicity evaluation in mice

N Wang, Z Wang, M Ma, X Jia, H Liu, M Qian… - International Journal of …, 2023 - Elsevier
Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that
mainly infects piglets, and causes huge losses to the pig industry. However, there are still no …

SARS‐CoV‐2 Spike Stem Protein Nanoparticles Elicited Broad ADCC and Robust Neutralization against Variants in Mice

Y Ma, Y Wang, C Dong, GX Gonzalez, W Zhu, J Kim… - Small, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the global
pandemic. The virus is rapidly evolving, characterized by the emergence of several major …

Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B …

Y Zhou, T Zhang, Z Wang, X Xu - Virology Journal, 2025 - Springer
Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control
existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are …

Immunization with a mucosal, post-fusion F/G protein-based polyanhydride nanovaccine protects neonatal calves against BRSV infection

TW Maina, EA Grego, S Broderick, RE Sacco… - Frontiers in …, 2023 - frontiersin.org
Human respiratory syncytial virus (HRSV) is a leading cause of death in young children and
there are no FDA approved vaccines. Bovine RSV (BRSV) is antigenically similar to HRSV …

[HTML][HTML] Challenges for the newborn immune response to respiratory virus infection and vaccination

KF Crofts, MA Alexander-Miller - Vaccines, 2020 - mdpi.com
The initial months of life reflect an extremely challenging time for newborns as a naïve
immune system is bombarded with a large array of pathogens, commensals, and other …

Respiratory syntycial virus: current treatment strategies and vaccine approaches

EM Thornhill, J Salpor… - Antiviral Chemistry and …, 2020 - journals.sagepub.com
Respiratory Syncytial Virus is a yearly respiratory virus that causes significant frequencies of
morbidities, particularly in the young and elderly populations. However, preventive vaccines …

Molecular evaluation of oral immunogenicity of hepatitis B antigen delivered by hydrogel microparticles

XY Chen, AM Butt, MCI Mohd Amin - Molecular Pharmaceutics, 2019 - ACS Publications
The development of oral vaccine formulation is crucial to facilitate an effective mass
immunization program for various vaccine-preventable diseases. In this work, the efficacy of …