Pathogenesis of triple-negative breast cancer
Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …
fundamentally different diseases with different histologic, genomic, and immunologic …
The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing
Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
resistance to chemotherapy. An unresolved question is whether resistance is caused by the …
Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
A practical guide to cancer subclonal reconstruction from DNA sequencing
Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …
evolution studies, providing insight into the clonality and relative ordering of mutations and …
[HTML][HTML] Multiclonal invasion in breast tumors identified by topographic single cell sequencing
Ductal carcinoma in situ (DCIS) is an early-stage breast cancer that infrequently progresses
to invasive ductal carcinoma (IDC). Genomic evolution has been difficult to delineate during …
to invasive ductal carcinoma (IDC). Genomic evolution has been difficult to delineate during …
Advancing cancer research and medicine with single-cell genomics
Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
Unravelling biology and shifting paradigms in cancer with single-cell sequencing
The fundamental operative unit of a cancer is the genetically and epigenetically innovative
single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated …
single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated …
Tumor functional heterogeneity unraveled by scRNA-seq technologies
Effective cancer treatment has been precluded by the presence of various forms of
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …
Overview on clinical relevance of intra-tumor heterogeneity
G Stanta, S Bonin - Frontiers in medicine, 2018 - frontiersin.org
Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …