Acquisition and analysis of DIA-based proteomic data: A comprehensive survey in 2023
R Lou, W Shui - Molecular & Cellular Proteomics, 2024 - ASBMB
Data-independent acquisition (DIA) mass spectrometry (MS) has emerged as a powerful
technology for high-throughput, accurate, and reproducible quantitative proteomics. This …
technology for high-throughput, accurate, and reproducible quantitative proteomics. This …
What can ribo-seq, immunopeptidomics, and proteomics tell us about the noncanonical proteome?
Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …
the human genome and proteome by illuminating thousands of noncanonical sites of …
Thunder-DDA-PASEF enables high-coverage immunopeptidomics and is boosted by MS2Rescore with MS2PIP timsTOF fragmentation prediction model
D Gomez-Zepeda, D Arnold-Schild, J Beyrle… - Nature …, 2024 - nature.com
Human leukocyte antigen (HLA) class I peptide ligands (HLAIps) are key targets for
develo** vaccines and immunotherapies against infectious pathogens or cancer cells …
develo** vaccines and immunotherapies against infectious pathogens or cancer cells …
[HTML][HTML] Rescoring Peptide Spectrum Matches: Boosting Proteomics Performance by Integrating Peptide Property Predictors into Peptide Identification
Rescoring of peptide spectrum matches originating from database search engines enabled
by peptide property predictors is exceeding the performance of peptide identification from …
by peptide property predictors is exceeding the performance of peptide identification from …
OpenProt 2.0 builds a path to the functional characterization of alternative proteins
The OpenProt proteogenomic resource (https://www. openprot. org/) provides users with a
complete and freely accessible set of non-canonical or alternative open reading frames …
complete and freely accessible set of non-canonical or alternative open reading frames …
The Proteomics Standards Initiative standardized formats for spectral libraries and fragment ion peak annotations: mzSpecLib and mzPAF
Mass spectral libraries are collections of reference spectra, usually associated with specific
analytes from which the spectra were generated, that are used for further downstream …
analytes from which the spectra were generated, that are used for further downstream …
ProHap enables human proteomic database generation accounting for population diversity
Amid the advances in genomics, the availability of large reference panels of human
haplotypes is key to account for human diversity within and across populations. However …
haplotypes is key to account for human diversity within and across populations. However …
Koina: Democratizing machine learning for proteomics research
Recent developments in machine-learning (ML) and deep-learning (DL) have immense
potential for applications in proteomics, such as generating spectral libraries, improving …
potential for applications in proteomics, such as generating spectral libraries, improving …
ADAM19 cleaves the PTH receptor and associates with brachydactyly type E
Brachydactyly type E (BDE), shortened metacarpals, metatarsals, cone-shaped epiphyses,
and short stature commonly occurs as a sole phenotype. Parathyroid hormone-like protein …
and short stature commonly occurs as a sole phenotype. Parathyroid hormone-like protein …
Proteogenomics analysis of human tissues using pangenomes
The genomics landscape is evolving with the emergence of pangenomes, challenging the
conventional single-reference genome model. The new human pangenome reference …
conventional single-reference genome model. The new human pangenome reference …