The role of HER2 in cancer therapy and targeted drug delivery
HER2 is highly expressed in a significant proportion of breast cancer, ovarian cancer, and
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …
Peptides used in the delivery of small noncoding RNA
RNA interference (RNAi) is an endogenous process in which small noncoding RNAs,
including small interfering RNAs (siRNAs) and microRNAs (miRNAs), post-transcriptionally …
including small interfering RNAs (siRNAs) and microRNAs (miRNAs), post-transcriptionally …
Multi-modal multi-instance learning using weakly correlated histopathological images and tabular clinical information
The fusion of heterogeneous medical data is essential in precision medicine to assist
medical experts in treatment decision-making. However, there is often little explicit …
medical experts in treatment decision-making. However, there is often little explicit …
Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance
M Lei, G Ma, S Sha, X Wang, H Feng, Y Zhu, X Du - Drug delivery, 2019 - Taylor & Francis
Multidrug resistance (MDR) remains one of the major reasons for inefficiency of many
chemotherapeutic agents in cancer therapy. In this study, a D-α-tocopheryl polyethylene …
chemotherapeutic agents in cancer therapy. In this study, a D-α-tocopheryl polyethylene …
[HTML][HTML] Development of a biocompatible copolymer nanocomplex to deliver VEGF siRNA for triple negative breast cancer
Triple negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat.
TNBC patients have significantly higher expression of vascular endothelial growth factor …
TNBC patients have significantly higher expression of vascular endothelial growth factor …
Effective gene silencing by multilayered siRNA‐coated gold nanoparticles
Small interfering RNA (siRNA) has been widely proposed to treat various diseases by
silencing genes, but its delivery remains a challenge. A well controlled assembly approach …
silencing genes, but its delivery remains a challenge. A well controlled assembly approach …
Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo
SJ Lee, S Yook, JY Yhee, HY Yoon, MG Kim… - Journal of Controlled …, 2015 - Elsevier
Cancer is a multifactorial disease which involves complex genetic mutation and
dysregulation. Combinatorial RNAi technology and concurrent multiple gene silencing are …
dysregulation. Combinatorial RNAi technology and concurrent multiple gene silencing are …
Expression profile and functional activity of peptide transporters in prostate cancer cells
Peptide transporters are expressed predominantly in intestinal and renal epithelial cells. The
functional expression of peptide transporters is also identified in other types of tissues, such …
functional expression of peptide transporters is also identified in other types of tissues, such …
Bispecific antibody-based immune-cell engagers and their emerging therapeutic targets in cancer immunotherapy
HG Shin, HR Yang, A Yoon, S Lee - International Journal of Molecular …, 2022 - mdpi.com
Cancer is the second leading cause of death worldwide after cardiovascular diseases.
Harnessing the power of immune cells is a promising strategy to improve the antitumor effect …
Harnessing the power of immune cells is a promising strategy to improve the antitumor effect …
Intracellular trafficking and exocytosis of a multi-component siRNA nanocomplex
Despite the importance of siRNA delivery systems, understanding of their intracellular fate
remains elusive. We recently developed a multi-component siRNA nanocomplex to deliver …
remains elusive. We recently developed a multi-component siRNA nanocomplex to deliver …