A reversible structural unlocking reaction, in which the close-packed van der Waals
interactions break cooperatively, has been found for the villin headpiece subdomain (HP35) …

As the fastest folding protein, the villin headpiece (HP35) serves as an important bridge
between simulation and experimental studies of protein folding. Despite the simplicity of this …

We have investigated microsecond to millisecond time scale dynamics in several key
hydrophobic core methyl groups of chicken villin headpiece subdomain protein (HP36) …

With the goal of investigating dynamical features of hydrophobic cores of proteins over a
wide range of temperatures, the chicken villin headpiece subdomain protein (HP36) was …

We investigated site-specific dynamics of key methyl groups in the hydrophobic core of
chicken villin headpiece subdomain (HP36) over the temperature range between 298 and …

The synchronization of native state motions as they transition between microstates
influences catalysis kinetics, mediates allosteric interactions, and reduces the …

Abstract Abstract Nuclear Magnetic Resonance (NMR) relaxation is a powerful technique
that provides information about internal dynamics associated with configurational energetics …

The villin headpiece helical subdomain (HP36) is one of the best known model systems for
computational studies of fast‐folding all‐α miniproteins. HP21 is a peptide fragment …

Crucial to the function of proteins is their existence as conformational ensembles sampling
numerous and structurally diverse substates. Despite this widely accepted notion there is …

Although NMR relaxation phenomena provide a great deal of insight into local molecular
dynamics, the dynamic picture of biomacromolecules is still largely incomplete, as no …